ethyl 2-phenylimidazo[1,2-b]pyridazine-3-acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-phenylimidazo[1,2-b]pyridazine-3-acetate
• 英文别名: Ethyl 2-(2-phenylimidazo[1,2-b]pyridazin-3-yl)acetate
• 化学式: C₁₆H₁₅N₃O₂
• 分子量: 281.314
• InChiKey: SCDDTMUSCRGHQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-phenylimidazo[1,2-b]pyridazine-3-acetate 在 盐酸 作用下， 以55%的产率得到2-phenylimidazo[1,2-b]pyridazine-3-acetic acid
  参考文献：
  名称：

  Research on heterocyclic compounds, XLI. 2-Phenylimidazo[1,2-b]pyridazine-3-acetic derivatives: synthesis and anti-inflammatory activity

  摘要：

  The synthesis of a group of 2-phenylimidazo[1,2-b]pyridazine-3-acetic esters and acids is described. The structures of the new compounds are supported by H-1-NMR spectra. These compounds were tested in vivo for their anti-inflammatory, analgesic and ulcerogenic activity. All new compounds showed remarkable anti-inflammatory action in the carrageenan rat paw oedema (one third of that for indomethacin) but no significant analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action, and were also found to be lacking inhibitory activity on cyclooxygenase in vitro. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(99)00112-9
• 作为产物：
  描述：

  哒嗪-3-胺 、 3-苯甲酰基-3-溴丙酸乙酯 以 Petroleum ether 为溶剂， 反应 3.0h， 以32%的产率得到ethyl 2-phenylimidazo[1,2-b]pyridazine-3-acetate
  参考文献：
  名称：

  Research on heterocyclic compounds, XLI. 2-Phenylimidazo[1,2-b]pyridazine-3-acetic derivatives: synthesis and anti-inflammatory activity

  摘要：

  The synthesis of a group of 2-phenylimidazo[1,2-b]pyridazine-3-acetic esters and acids is described. The structures of the new compounds are supported by H-1-NMR spectra. These compounds were tested in vivo for their anti-inflammatory, analgesic and ulcerogenic activity. All new compounds showed remarkable anti-inflammatory action in the carrageenan rat paw oedema (one third of that for indomethacin) but no significant analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action, and were also found to be lacking inhibitory activity on cyclooxygenase in vitro. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(99)00112-9

文献信息

• Research on heterocyclic compounds, XLI. 2-Phenylimidazo[1,2-b]pyridazine-3-acetic derivatives: synthesis and anti-inflammatory activity
  作者：Antonia Sacchi、Sonia Laneri、Francesca Arena、Enrico Abignente、Marina Gallitelli、Michele D'amico、Walter Filippelli、Francesco Rossi

  DOI：10.1016/s0223-5234(99)00112-9

  日期：1999.11

  The synthesis of a group of 2-phenylimidazo[1,2-b]pyridazine-3-acetic esters and acids is described. The structures of the new compounds are supported by H-1-NMR spectra. These compounds were tested in vivo for their anti-inflammatory, analgesic and ulcerogenic activity. All new compounds showed remarkable anti-inflammatory action in the carrageenan rat paw oedema (one third of that for indomethacin) but no significant analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action, and were also found to be lacking inhibitory activity on cyclooxygenase in vitro. (C) 1999 Editions scientifiques et medicales Elsevier SAS.