(3E)-6-fluoro-3-[4-{5-[(4-hydroxypiperidin-1-yl)methyl]-3-thienyl}-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3E)-6-fluoro-3-[4-{5-[(4-hydroxypiperidin-1-yl)methyl]-3-thienyl}-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one
• 英文别名: (3E)-6-fluoro-3-[4-[5-[(4-hydroxypiperidin-1-yl)methyl]thiophen-3-yl]-5,5-dimethylfuran-2-ylidene]-1H-indol-2-one
• 化学式: C₂₄H₂₅FN₂O₃S
• 分子量: 440.539
• InChiKey: NBXMPASVUGGBMA-QURGRASLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  90
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基哌啶 、 4-[(5E)-5-(6-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]thiophene-2-carbaldehyde 在 溶剂黄146 、 sodium cyanoborohydride 、 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 、 甲醇 、 水 为溶剂， 反应 19.0h， 以26%的产率得到(3E)-6-fluoro-3-[4-{5-[(4-hydroxypiperidin-1-yl)methyl]-3-thienyl}-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one
  参考文献：
  名称：

  SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL-1, 3-DIHYDRO-INDOL-2-ONE'S AND DERIVATIVES THEREOF AS KINASE INHIBITORS

  摘要：

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调控、调节和/或抑制异常细胞增殖。

  公开号：

  US20070173500A1

文献信息

• Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors
  申请人：Allergan, Inc.

  公开号：US08338415B2

  公开（公告）日：2012-12-25

  The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, as disclosed herein. The present invention also relates to pharmaceutical compositions comprising said compounds and to methods of using said compounds and compositions for modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及以下式I的化合物：或其药学上可接受的盐，如本文所述。本发明还涉及含有所述化合物的制药组合物，以及使用所述化合物和组合物调节酪氨酸激酶信号转导以调节、调节和/或抑制异常细胞增殖的方法。
• Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-ones and derivatives thereof as kinase inhibitors
  申请人：Allergan, Inc.

  公开号：US08877923B2

  公开（公告）日：2014-11-04

  The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调节、调制和/或抑制异常细胞增殖。
• SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL-1, 3-DIHYDRO-INDOL-2-ONES AND DERIVATIVES THEREOF AS KINASE INHIBITORS
  申请人：Allergan, Inc.

  公开号：US20130123259A1

  公开（公告）日：2013-05-16

  The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调节、调控和/或抑制异常细胞增殖。
• Treatment composition for making acquisition fluff pulp in sheet form
  申请人：Hamed A. Othman

  公开号：US20060184147A1

  公开（公告）日：2006-08-17

  A treatment composition for making acquisition fluff pulp in sheet form, having a cross-linking agent and an anti-hydrogen-bonding agent. The cross-linking agent may be a polycarboxylic acid, aldehyde, urea-based derivatives or a mixture thereof. The anti-hydrogen-bonding agent may be a silicon polymer terminated with at least one quaternary amine functional group. A method of making acquisition fluff pulp using the treatment composition involves treating a cellulosic base fiber with a treatment composition solution to impregnate the fiber with the treatment composition, and then drying and curing the impregnated fiber. The resultant acquisition fluff pulp may be utilized in an acquisition layer and/or an absorbent core of an absorbent article intended for body waste management.

  一种用于制造片状采集绒毛浆的处理组合物，其中含有一种交联剂和一种抗氢键剂。交联剂可以是聚羧酸、醛、脲基衍生物或它们的混合物。抗氢键剂可以是以至少一个季胺官能团为端基的硅聚合物。使用处理组合物制造绒毛浆的方法包括用处理组合物溶液处理纤维素基纤维，使纤维浸渍处理组合物，然后干燥和固化浸渍纤维。由此产生的吸附绒毛浆可用于吸附层和/或用于人体废物管理的吸附制品的吸芯。
• Acquisition fiber in sheet form with low degree of yellowing and low odor
  申请人：Hamed A. Othman

  公开号：US20070020452A1

  公开（公告）日：2007-01-25

  A method for making acquisition fiber in sheet form that exhibits a low degree of yellowing and is substantially free of burnt-like odor. The acquisition fiber may be produced by treating cellulosic fibers in sheet form with a treatment composition solution that includes a cross-linking agent and a modifying agent. After the fibers are impregnated with the treatment composition, the fibers are dried and cured, and then treated with an odor removing agent. The resultant acquisition fiber may be used in absorbent articles, such as personal care products.