2-methylthiazole-5-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methylthiazole-5-sulfonamide
• 英文别名: methylthiazole-5-sulfonamide；2-Methyl-1,3-thiazole-5-sulfonamide
• 化学式: C₄H₆N₂O₂S₂
• mdl: MFCD18822170
• 分子量: 178.236
• InChiKey: SVVRRPMUSIFOOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-二氯苯甲酸 、 2-methylthiazole-5-sulfonamide 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 2,4-dichloro-N-[(2-methyl-1,3-thiazol-5-yl)sulfonyl]benzamide
  参考文献：
  名称：

  Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

  摘要：

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.041
• 作为产物：
  描述：

  2-methylthiazole-5-sulfonyl chloride 在 ammonium hydroxide 作用下， 生成 2-methylthiazole-5-sulfonamide
  参考文献：
  名称：

  Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

  摘要：

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.041

文献信息

• Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
  作者：Christopher McBride、Lynnie Trzoss、Davide Povero、Milos Lazic、Geza Ambrus-Aikelin、Angelina Santini、Rama Pranadinata、Gretchen Bain、Ryan Stansfield、Jeffrey A. Stafford、James Veal、Ryan Takahashi、Justin Ly、Shu Chen、Liling Liu、Marika Nespi、Robert Blake、Arna Katewa、Tracy Kleinheinz、Swathi Sujatha-Bhaskar、Nandhini Ramamoorthi、Jessica Sims、Brent McKenzie、Mark Chen、Mark Ultsch、Matthew Johnson、Jeremy Murray、Claudio Ciferri、Steven T. Staben、Michael J. Townsend、Craig E. Stivala

  DOI：10.1021/acs.jmedchem.2c01250

  日期：2022.11.10
• Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
  作者：Mary M. Mader、Chuan Shih、Eileen Considine、Alfonso De Dios、Cora Sue Grossman、Philip A. Hipskind、Ho-Shen Lin、Karen L. Lobb、Beatriz Lopez、José E. Lopez、Luisa M. Martin Cabrejas、Michael E. Richett、Wesley T. White、Yiu-Yin Cheung、Zhongping Huang、John E. Reilly、Sean R. Dinn

  DOI：10.1016/j.bmcl.2004.11.041

  日期：2005.2

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.