1,1'-bis(o-tolyl)-5,5'-diphenyl-3,3'-bipyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,1'-bis(o-tolyl)-5,5'-diphenyl-3,3'-bipyrazole
• 英文别名: 1-(2-Methylphenyl)-3-[1-(2-methylphenyl)-5-phenylpyrazol-3-yl]-5-phenylpyrazole
• 化学式: C₃₂H₂₆N₄
• 分子量: 466.585
• InChiKey: FKFTUWFZZHSMQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1Z,5Z)-1,6-dihydroxy-1,6-diphenylhexa-1,5-diene-3,4-dione 、 (2-甲基苯基)肼 以 溶剂黄146 为溶剂， 以44%的产率得到1,1'-bis(o-tolyl)-5,5'-diphenyl-3,3'-bipyrazole
  参考文献：
  名称：

  摘要：

  Reactions of 1,6-disubstituted 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine hydrate or hydrochloride afforded heterocyclization products, 3,3'-bipyrazoles. The chemoselective reaction of 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-diones with arylhydrazines gave rise to 1,1',5,5'-tetraaryl-3,3'-bipyrazoles and 1,5-diaryl-3-aroylacetylpyrazoles. The specific structural features of the pyrazole derivatives obtained are discussed. Some pyrazoles show bacteriostatic and antileukemic activity.

  DOI：

  10.1023/a:1013431407273

文献信息

• ——
  作者：T. M. Shironina、N. M. Igidov、E. N. Koz'minykh、L. O. Kon'shina、Yu. S. Kasatkina、V. O. Koz'minykh

  DOI：10.1023/a:1013431407273

  日期：——

  Reactions of 1,6-disubstituted 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine hydrate or hydrochloride afforded heterocyclization products, 3,3'-bipyrazoles. The chemoselective reaction of 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-diones with arylhydrazines gave rise to 1,1',5,5'-tetraaryl-3,3'-bipyrazoles and 1,5-diaryl-3-aroylacetylpyrazoles. The specific structural features of the pyrazole derivatives obtained are discussed. Some pyrazoles show bacteriostatic and antileukemic activity.