(1R,2R,3S,11bS)-1,3-二羟基-2-甲氧基-11b-甲基-1,2,3,7,8,11b-六氢环戊二烯并[7,8]菲并[10,1-bc]呋喃-6,9-二酮 | 23820-80-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: (1R,2R,3S,11bS)-1,3-二羟基-2-甲氧基-11b-甲基-1,2,3,7,8,11b-六氢环戊二烯并[7,8]菲并[10,1-bc]呋喃-6,9-二酮
• 中文别名: 绿毛菌醇
• 英文名称: Viridiol
• 英文别名: (1R,16R,17S,18S)-16,18-dihydroxy-17-methoxy-1-methyl-13-oxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),3,5(9),12(19),14-pentaene-6,11-dione
• CAS: 23820-80-6
• 化学式: C₂₀H₁₈O₆
• 分子量: 354.4
• InChiKey: JZAFRYPNQHUUMQ-HUYLIWGRSA-N

物化性质

• 沸点：
  504.7±50.0 °C(Predicted)
• 密度：
  1.51±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Insulin-producing cells derived from stem cells
  申请人：Hori Yuichi

  公开号：US20070154981A1

  公开（公告）日：2007-07-05

  The disclosure provides, among other things, insulin-producing cells derived from stem cells, such as human stem cells and neural stem cells. The disclosure discloses a relationship between caudalizing factors and the differentiation of insulin-producing cells.

  该披露提供了从干细胞（如人类干细胞和神经干细胞）衍生出的胰岛素产生细胞，其中包括其他内容。该披露揭示了尾端因子与胰岛素产生细胞分化之间的关系。
• Wortmannin conjugates and uses thereof
  申请人：Yuan Hushan

  公开号：US20090324489A1

  公开（公告）日：2009-12-31

  The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3-kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.

  本发明涉及沃特曼宁及其衍生物的共轭物，并将其用作PI3-激酶活性抑制剂，用于治疗癌症、炎症性疾病和C. albicans感染。
• COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
  申请人：REGENERATIVE MEDICAL SOLUTIONS, INC.

  公开号：US20160083693A1

  公开（公告）日：2016-03-24

  Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.

  本发明提供了培养多能干细胞以产生包含β细胞（例如胰腺系谱、对葡萄糖敏感和/或产生胰岛素）的细胞群的方法、试剂盒、组合物和系统。特别地，提供了一种培养条件，从人类多能干细胞的起始培养中产生β细胞的方法。
• Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
  申请人：ELI LILLY AND COMPANY

  公开号：EP0648492A3

  公开（公告）日：1997-02-26

  Viridin, viridiol, demethoxyviridin, demethoxyviridiol, virone, and wortmannolone, and analogs thereof, are inhibitors of phosphatidylinositol 3-kinase. The compounds are particularly useful for inhibiting phosphatidylinositol 3-kinase in vertebrates and for treating phosphatidylinositol 3-kinase-dependent conditions, especially neoplasms, restenosis and atherosclerosis, and bone disorders in vertebrates.

  病毒素、病毒唑、去甲氧基病毒素、去甲氧基病毒唑、病毒酮和沃特曼龙及其类似物是磷脂酰肌醇 3- 激酶的抑制剂。这些化合物特别适用于抑制脊椎动物体内的磷脂酰肌醇 3-激酶，以及治疗依赖磷脂酰肌醇 3-激酶的疾病，尤其是脊椎动物体内的肿瘤、血管再狭窄和动脉粥样硬化以及骨骼疾病。