局丙二醇硬脂醚 | 25231-21-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 局丙二醇硬脂醚
• 中文别名: PPG-15硬脂基醚；α-十八烷基-ω-羟基聚1,2-丙二醇；PPG-15硬脂醇醚；PPG-11硬脂基醚；PPG-11硬脂醇醚；聚甲基环氧乙烷十八烷基醚；聚-1,2-丙二醇十八烷基醚；-十八烷基-&omega；-羟基聚1,2-丙二醇；聚-1,2-丙
• 英文名称: 1-octadecyloxy-propan-2-ol
• 英文别名: 1-Octadecoxypropan-2-ol
• CAS: 25231-21-4
• 化学式: C₂₁H₄₄O₂
• 分子量: 328.579
• InChiKey: ZQCIPRGNRQXXSK-UHFFFAOYSA-N

物化性质

• LogP：
  8.320 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds, compositions and methods for the treatment of viral infections and other medical disorders
  申请人：Almond R. Merrick

  公开号：US20070003608A1

  公开（公告）日：2007-01-04

  The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes.

  本申请提供了一种提高含脂质抗病毒化合物的生物利用度的方法和组合物，尤其是一种含脂质抗病毒化合物。在一种实施例中，提供了药学上可接受的组合物，其中包括一种含脂质抗病毒化合物或其盐、酯或前药，以及一种或多种生物利用度增强化合物，例如细胞色素P450酶抑制剂。
• Carriers, Formulations, Methods For Formulating Unstable Active Agents For External Application And Uses Thereof
  申请人：Foamix Ltd.

  公开号：US20130189191A1

  公开（公告）日：2013-07-25

  The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.

  本公开教授了一种独特的四环素类抗生素外用给药配方，其中四环素类抗生素保持稳定。
• CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF
  申请人：Tamarkin Dov

  公开号：US20100310476A1

  公开（公告）日：2010-12-09

  The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.

  本公开教授了独特的四环素类抗生素局部给药配方，其中四环素类抗生素保持稳定。
• FRAGRANCE COMPOSITIONS AND USES THEREOF
  申请人：The Procter & Gamble Company

  公开号：EP3141239A1

  公开（公告）日：2017-03-15

  The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.

  本发明涉及一种具有改进或增强的香味保真度和/或持久性的组合物，该组合物由钻石结构的香味材料和至少一种基本无臭的香味调节剂组成。本发明还涉及组合物的使用方法，用于对合适的基底（包括硬表面和身体部位，特别是皮肤和头发）进行加香。
• COSMETIC WATER-IN-OIL MICROEMULSION
  申请人：Ionia Azure AG

  公开号：EP3308766A1

  公开（公告）日：2018-04-18

  A cosmetic water-in-oil microemulsion having advantageous rheological properties comprising: i) 20 - 40% w/w of oil phase ingredients with spreadability value of above 1700 mm2/10 min, ii) 15 - 35% w/w of oil phase ingredients with spreadability value between 1000 and 1700 mm2/10 min, iii) 1 - 15% w/w of oil phase ingredients with spreadability value between 500 and 999 mm2/10 min, iv) 0 - 10 % w/w of oil phase ingredients with spreadability value of below 500 mm2/10 min, v) 5 - 30 % w/w of fatty acid ester(s) of glycerol or fatty acid ester(s) of polyglycerol, vi) 5 - 20% w/w of water, co-surfactant(s) and optionally co-solvent(s), cosmetic active ingredient(s), skin care ingredient(s), water-soluble extract(s) of plant material and cosmetic auxiliary ingredient(s).

  一种具有良好流变特性的油包水化妆品微乳液，包括i) 20 - 40% w/w 油相成分，延展性高于 1700 mm2/10 min； ii) 15 - 35% w/w 油相成分，延展性介于 1000 和 1700 mm2/10 min； iii) 1 - 15% w/w 油相成分，延展性介于 500 和 999 mm2/10 min； iv) 0 - 10 % w/w 油相成分，延展性低于 500 mm2/10 min、v) 5 - 30% w/w 的甘油脂肪酸酯或聚甘油脂肪酸酯， vi) 5 - 20% w/w 的水、助表面活性剂和可选的助溶剂、化妆品活性成分、护肤成分、水溶性 植物提取物和化妆品辅助成分。