(1Z,2S)-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxysulfonyl]-2-azaniumyl-5-hydroxy-5-oxopentanimidate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (1Z,2S)-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxysulfonyl]-2-azaniumyl-5-hydroxy-5-oxopentanimidate
• 化学式: C15H21N7O9S
• 分子量: 475.4
• InChiKey: YBRKRYFZKHICLS-WERHYGNASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  264
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• DUAL CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO SYNTHESIS METHOD
  申请人：Voloshin Alexei M.

  公开号：US20100184134A1

  公开（公告）日：2010-07-22

  This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.

  这项发明提供了一种新的方法，利用无细胞合成系统将非天然氨基酸并入蛋白质的预选位点。该方法涉及使用非正交的、由遗传密码编码的本地同义tRNA，以实现通过使用同义密码子并不依赖于正交tRNA合成酶对的情况下并入多种非天然氨基酸的目的。
• MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM
  申请人：Voloshin Alexei M.

  公开号：US20100184135A1

  公开（公告）日：2010-07-22

  This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.

  这项发明提供了一种新颖的方法，利用无细胞合成系统将非天然氨基酸纳入蛋白质的预选位点。该方法涉及使用由基因密码编码的非正交、本地同义tRNA，这些tRNA可接受相同的氨基酸。这种方法允许通过使用同义密码子纳入许多非天然氨基酸，而无需依赖正交tRNA合成酶对。
• US8778631B2
  申请人：——

  公开号：US8778631B2

  公开（公告）日：2014-07-15