(2E,4E)-十三碳二烯酸 | 151276-91-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (2E,4E)-十三碳二烯酸
• 英文名称: (2E,4E)-tridecadienoic acid
• 英文别名: trideca-2,4-dienoic acid；Trideca-2,4-diensaeure；trans,trans-2,4-tridecadienoic acid；Tridecadienoic acid；(2E,4E)-trideca-2,4-dienoic acid
• CAS: 151276-91-4
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: SUEKUALWVJZYCO-HULFFUFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E,4E)-十三碳二烯酸 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 6-<4-deoxy-4-<(2E,4E)-tridecadienoyl>glycylamino-L-glycero-β-L-manno-heptapyranosylamino>-9H-purine
  参考文献：
  名称：

  Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives.

  摘要：

  新合成了一系列在分子脂肪酸部分进行了修饰的斯匹卡霉素衍生物，并研究了它们的构效关系。通过对脂肪酸部分进行修饰，将其转化为十四碳二烯酸或十二碳二烯酸类似物，这些衍生物对COL-1人结肠癌异种移植模型的抗肿瘤活性显著优于SPM VIII。

  DOI：

  10.7164/antibiotics.48.1467
• 作为产物：
  描述：

  (2E,4E)-trideca-2,4-dienal 在 silver(l) oxide 作用下， 生成 (2E,4E)-十三碳二烯酸
  参考文献：
  名称：

  The clinical utility of the Hopkins Verbal Learning Test as a screening test for mild dementia

  摘要：

  Objective: The purpose of this study was to determine whether the Hopkins Verbal Learning Test (HVLT) could be used as a valid and reliable screening test for mild dementia in older people, and to compare its performance to that of the Mini-Mental State Examination (MMSE). Method: Using a cross-sectional design, we studied three groups of older subjects recruited from a district geriatric psychiatry service: (1) 26 patients with DSM-IV dementia and MMSE scores of 18 or better; (2) 15 patients with psychiatric diagnoses other than dementia; and (3) 15 normal controls. The relationship of each potential cutting point on the HVLT and the MMSE was examined against the independently ascertained DSM-IV diagnoses of dementia using a Receiver Operating Characteristic (ROC) analysis. Results: The subjects consisted of 21 (37.5%) males and 35 (62.5%) females with a mean age of 74.7 (SD 6.1) years and a mean of 8.5 (SD 1.8) years of formal education. ROC analysis indicated that the optimal cutting point for detecting mild dementia in this group of subjects using the HVLT was 18/19 (sensitivity=0.96, specificity=0.80) and using the MMSE was 25/26 (sensitivity=0.88, specificity=0.93). Conclusions: The HVLT can be recommended as a valid and reliable screening test for mild dementia and as an adjunct in the clinical assessment of older people. The HVLT had better sensitivity than the MMSE in detecting patients with mild dementia, whereas the MMSE had better specificity.

  DOI：

  10.1002/(sici)1099-1166(200004)15:4<317::aid-gps116>3.0.co;2-7

文献信息

• [EN] HIGH PURITY DIBASIC ACID COMPOSITIONS AND METHODS OF MAKING THE SAME<br/>[FR] COMPOSITIONS D'ACIDE DIBASIQUE DE PURETÉ ÉLEVÉE ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：ELEVANCE RENEWABLE SCIENCES

  公开号：WO2015053988A1

  公开（公告）日：2015-04-16

  High-purity dibasic acid compositions are generally disclosed. In some embodiments, the dibasic acid compositions are solutions or suspensions. In some other embodiments, the compositions are solid-state compositions. In some such embodiments, the solid-state compositions include a dibasic acid as a crystalline solid and further include a low quantity of certain impurities, such as monobasic acids, various esters, and the like. Methods and systems for making such high-purity dibasic acid compositions are also disclosed.

  高纯度的二元酸组合物通常被披露。在某些实施例中，二元酸组合物是溶液或悬浮液。在其他一些实施例中，组合物是固态组合物。在这样的一些实施例中，固态组合物包括二元酸作为晶体固体，并进一步包括低量的某些杂质，例如一元酸，各种酯等。还披露了制备这种高纯度二元酸组合物的方法和系统。
• Spicamycin derivatives and their use as anticancer agents
  申请人：Kirin Beer Kabushiki Kaisha

  公开号：US05461036A1

  公开（公告）日：1995-10-24

  Spicamycin derivative represented by the formula (I) or a salt thereof: ##STR1## wherein R represents specific diverse substituents, for example, a linear alkadienyl having from 11 to 13 carbon atoms, and R.sub.1 and R.sub.2 respectively represent H or OH. Examples of specific compounds are 6-[4'-N-(N'-trans,trans 2,4-tridecadienoylglycyl)spicaminyl-amino]purine, and 6-[4'-N-(N'-trans,trans-2,4 dodecadienyoly glycyl) spicaminyl-amino]purine. Comopunds according to this invention are useful as a pharmaceutical for inhibition of a tumor, for example, human colon cancer.

  公式（I）或其盐所代表的Spicamycin衍生物：##STR1## 其中R代表特定的多样化取代基，例如，具有11至13个碳原子的直链烯烃基，而R.sub.1和R.sub.2分别代表H或OH。具体化合物的例子包括6-[4'-N-(N'-反式、反式2,4-十三烯酰基甘氨酸)spicaminyl-氨基]嘌呤和6-[4'-N-(N'-反式、反式-2,4-十二烯酰基甘氨酸)spicaminyl-氨基]嘌呤。根据本发明的化合物可用作药物，用于抑制肿瘤，例如，人类结肠癌。
• METHODS OF REFINING AND PRODUCING FUEL AND SPECIALTY CHEMICALS FROM NATURAL OIL FEEDSTOCKS
  申请人：Cohen Steven A.

  公开号：US20130035502A1

  公开（公告）日：2013-02-07

  Methods are provided for refining natural oil feedstocks. The methods comprise reacting the feedstock with a low-molecular-weight olefin or mid-weight olefin in the presence of a metathesis catalyst under conditions sufficient to form a metathesized product comprising olefins and esters. In certain embodiments, the methods further comprise separating the olefins from the esters in the metathesized product. In certain embodiments, the methods further comprise transesterifying the esters in the presence of an alcohol to form a transesterified product.

  提供了一种精制天然油料的方法。该方法包括在存在交换催化剂的条件下，将油料与低分子量烯烃或中分子量烯烃反应，以形成包含烯烃和酯的交换产物。在某些实施例中，该方法还包括将交换产物中的烯烃与酯分离。在某些实施例中，该方法还包括在醇存在下对酯进行酯交换反应，以形成酯交换产物。
• Methods of Refining and Producing Fuel and Specialty Chemicals from Natural Oil Feedstocks
  申请人：Elevance Renewable Sciences, Inc.

  公开号：US20140336399A1

  公开（公告）日：2014-11-13

  Methods are provided for refining natural oil feedstocks. The methods include reacting the feedstock with a molar excess of low-molecular-weight olefins in the presence of a metathesis catalyst. In certain embodiments, the methods further include separating at least a portion of the unreacted low-molecular-weight olefins. In certain embodiments, the methods further include recycling the separated unreacted low-molecular-weight olefins.

  提供了一种精制天然油原料的方法。该方法包括在存在交换催化剂的情况下，将原料与低分子量烯烃的摩尔过量反应。在某些实施例中，该方法还包括分离至少部分未反应的低分子量烯烃。在某些实施例中，该方法还包括回收分离的未反应的低分子量烯烃。
• Methods of Refining and Producing Dibasic Esters and Acids from Natural Oil Feedstocks
  申请人：Elevance Renewable Sciences, Inc.

  公开号：US20150299613A1

  公开（公告）日：2015-10-22

  Methods are provided for refining natural oil feedstocks and producing dibasic esters and/or dibasic acids. The methods comprise reacting a terminal olefin with an internal olefin in the presence of a metathesis catalyst to form a dibasic ester and/or dibasic acid. In certain embodiments, the olefin esters are formed by reacting the feedstock in the presence of a metathesis catalyst under conditions sufficient to form a metathesized product comprising olefins and esters, separating the olefins from the esters in the metathesized product, and transesterifying the esters in the presence of an alcohol to form a transesterified product having olefin esters.

  提供了一种精炼天然油原料和生产二元酯和/或二元酸的方法。该方法包括在存在交换催化剂的情况下，将末端烯烃与内部烯烃反应，形成二元酯和/或二元酸。在某些实施例中，通过在存在交换催化剂的条件下反应原料，以形成包含烯烃和酯的交换产物，从中分离烯烃和酯，并在醇的存在下对酯进行转酯化反应，以形成具有烯烃酯的转酯化产物。