(2R,4R,5R,6R)-5-氨基-2,4-二羟基-6-(1,2,3-三羟基丙基)氧化烷-2-羧酸 | 114-04-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2R,4R,5R,6R)-5-氨基-2,4-二羟基-6-(1,2,3-三羟基丙基)氧化烷-2-羧酸
• 中文别名: (2R,4R,5R,6R)-5-氨基-2,4-二羟基-6-(1,2,3-三羟基丙基)四氢吡喃-2-羧酸
• 英文名称: (4S,5R,6R,7S,8R)-5-amino-4,6,7,8,9-pentahydroxy-2-oxononanoic acid
• CAS: 114-04-5
• 化学式: C₉H₁₇NO₈
• 分子量: 267.23
• InChiKey: BQINXKOTJQCISL-GRCPKETISA-N

物化性质

• 熔点：
  186 °C (decomp)(Solv: acetic acid (64-19-7))
• 沸点：
  653.9±55.0 °C(Predicted)
• 密度：
  1.650±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.7
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  182
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20140235575A1

  公开（公告）日：2014-08-21

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

  本发明提供了一种一锅多酶法，用于从简单糖起始材料制备UDP糖。该发明还提供了一种一锅多酶法，用于从简单糖起始材料制备寡糖。
• PHOTOBACTERIUM SP. ALPHA-2-6-SIALYLTRANSFERASE VARIANTS
  申请人：The Regents of the University of California

  公开号：US20160177275A1

  公开（公告）日：2016-06-23

  The present invention provides Photobacterium sp. JH-ISH-224 α2-6-sialyltransferase Psp26ST variants and expression cassettes, vectors, and host cells for expressing the Psp26ST variants. Methods of synthesizing sialylated products are also described.

  本发明提供了Photobacterium sp. JH-ISH-224 α2-6-唾液酸转移酶Psp26ST变异体及其表达盒、载体和宿主细胞，用于表达Psp26ST变异体。还描述了合成唾液酸化产物的方法。
• METHOD FOR SPECIFICALLY LABELING LIVING BACTERIA
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：US20140363817A1

  公开（公告）日：2014-12-11

  The present invention concerns a method for labeling specifically living bacteria of a given category in a sample, the method including: a) incubating said bacteria of said sample with at least one analog of a monosaccharide compound, and b) contacting the bacteria with a labeling molecule having a second reactive group.

  本发明涉及一种用于在样品中特异性标记给定类别的活菌的方法，该方法包括：a）将所述样品中的所述菌株与至少一种单糖化合物的类似物一起孵育，并b）将该菌株与具有第二反应性基团的标记分子接触。
• A method for specifically detecting living bacteria
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2617833A1

  公开（公告）日：2013-07-24

  The present invention concerns a method for detecting specifically living bacteria of a given category of bacteria in a sample comprising bacteria, the method comprising the steps of: a) incubating said bacteria of said sample with an analog of a monosaccharide compound, said monosaccharide being an endogenous monosaccharide residue of glycans of the outer membrane of such given category of bacteria, the said endogenous monosaccharide residue comprising an ulosonic acid or ulosonate salt residue, the said analog of a monosaccharide compound being a modified monosaccharide substituted at a given position by a first reactive chemical group capable to react with a second reactive group of a detectable molecule, and b) contacting said bacteria with a said detectable molecule comprising a said second reactive group, for generating the reaction of said first reactive group of said analog residue incorporated within said glycans of the outer membrane of said bacteria with said second reactive group of said detectable, and c) detecting whether said bacteria comprise said detectable molecule bound to the glycans of their outer membrane.

  本发明涉及一种在包含细菌的样品中检测特定类别细菌的方法，该方法包括以下步骤： a) 用单糖化合物类似物培养所述样品中的所述细菌，所述单糖是该类细菌外膜糖的内源性单糖残基、所述内源性单糖残基包括一个溃疡酸或溃疡酸盐残基，所述单糖化合物类似物是在给定位置被能够与可检测分子的第二活性基团反应的第一活性化学基团取代的改性单糖，以及 b) 将所述细菌与包含所述第二活性基团的所述可检测分子接触，以产生包含在所述细菌外膜聚糖中的所述类似残基的所述第一活性基团与所述可检测分子的所述第二活性基团的反应，以及 c) 检测所述细菌的外膜聚糖上是否包含所述可检测分子。
• APTAMER-MODIFIED POLYMERIC MATERIALS FOR FOR USE AS A FOAM IN A WOUND DRESSING
  申请人：KCI Licensing, Inc.

  公开号：EP3272766A1

  公开（公告）日：2018-01-24

  The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the aptamer-modified materials can be polypeptides conjugated to polymer foam materials. Such materials may be used, for example, for dressings, wound inserts, or pads.

  本发明提供了可用于伤口床因子结合的适配体修饰聚合物及其材料。例如，适配体修饰的材料可以是与聚合物泡沫材料共轭的多肽。此类材料可用于敷料、伤口衬垫或衬垫等。