巯基-八聚乙二醇-醇 | 791620-96-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 巯基-八聚乙二醇-醇
• 英文名称: Thiol-PEG8-alcohol
• 英文别名: 2-[2-[2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• CAS: 791620-96-7
• 化学式: C₁₆H₃₄O₈S
• 分子量: 386.507
• InChiKey: FGOUEOBRQFJQKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  25
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-[2-[2-氯-3-[(1,3-二氢-1,3,3-三甲基-2H-吲哚-2-亚基)乙亚基]-1-环戊烯-1-基]乙烯基]-1,3,3-三甲基吲哚碘化物 、 巯基-八聚乙二醇-醇 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到2-((E)-2-((E)-2-(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricosylthio)-3-((E)-2-(1,3,3-trimethylindolin-2-ylidene)ethylidene)cyclohex-1-enyl)vinyl)-1,3,3-trimethyl-3H-indolium iodide
  参考文献：
  名称：

  Hoechst-IR: An Imaging Agent That Detects Necrotic Tissue in Vivo by Binding Extracellular DNA

  摘要：

  Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential. We demonstrate here that a small molecule, termed Hoechst-IR, composed of the DNA binding dye Hoechst and the near-infrared dye IR-786, can image necrotic tissue in vivo via fluorescence imaging. Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/D-galactosamine (LPS-GalN) induced sepsis.

  DOI：

  10.1021/ol100923d

文献信息

• DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY
  申请人：Hong Rui

  公开号：US20130122516A1

  公开（公告）日：2013-05-16

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
• US9291597B2
  申请人：——

  公开号：US9291597B2

  公开（公告）日：2016-03-22
• Hoechst-IR: An Imaging Agent That Detects Necrotic Tissue in Vivo by Binding Extracellular DNA
  作者：Madhuri Dasari、Sungmun Lee、Jay Sy、Dongin Kim、Seungjun Lee、Milton Brown、Michael Davis、Niren Murthy

  DOI：10.1021/ol100923d

  日期：2010.8.6

  Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential. We demonstrate here that a small molecule, termed Hoechst-IR, composed of the DNA binding dye Hoechst and the near-infrared dye IR-786, can image necrotic tissue in vivo via fluorescence imaging. Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/D-galactosamine (LPS-GalN) induced sepsis.