(3,4-二氯苯基)-哌啶-4-甲酮盐酸盐 | 64638-17-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (3,4-二氯苯基)-哌啶-4-甲酮盐酸盐
• 英文名称: (3,4-dichloro-phenyl)-piperidin-4-yl-methanone; hydrochloride
• 英文别名: 4-(3,4-dichlorobenzoyl)piperidine hydrochloride；(3,4-Dichlorophenyl)(piperidin-4-yl)methanone hydrochloride；(3,4-dichlorophenyl)-piperidin-4-ylmethanone;hydrochloride
• CAS: 64638-17-1
• 化学式: C₁₂H₁₃Cl₂NO*ClH
• mdl: MFCD08544118
• 分子量: 294.608
• InChiKey: UKWAMYCXWLQTBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  29.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2-氯-10-(3-氯丙基)-10H-吩噻嗪 、 (3,4-二氯苯基)-哌啶-4-甲酮盐酸盐 在 碳酸氢钠 作用下， 以 正丁醇 为溶剂， 反应 18.0h， 生成 {1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperidin-4-yl}-(3,4-dichloro-phenyl)-methanone
  参考文献：
  名称：

  [1-[3-(Phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones, a novel class of long-acting neuroleptic agents

  摘要：

  In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as the end points. Most compounds were shown to be potent neuroleptic agents and two were found to possess a long duration of action.

  DOI：

  10.1021/jm00199a029

文献信息

• N-substituted alpha-arylazacycloalkylmethanamines and their use as
  申请人：A. H. Robins Company Incorporated

  公开号：US05198449A1

  公开（公告）日：1993-03-30

  Novel compounds of the formula below wherein W is azetidine, pyrrolidine or piperidine, Q is a straight chain hydrocarbon radical of 1-4 carbons and may contain a double bond, and ##STR1## Ar is phenyl, pyridinyl or pyrimidinyl, a process for their preparation, and novel intermediates are disclosed. The novel compounds and the pharmaceutical compositions of this invention are useful in the treatment of hypertension, arrhythmias and angina.

  以下是该公式的新化合物，其中W为氮杂环丙烷、吡咯烷或哌嗪，Q为含有1-4个碳原子的直链烃基，可能含有双键，Ar为苯基、吡啶基或嘧啶基。公开了它们的制备方法和新型中间体。该发明的新化合物和药物组合物在治疗高血压、心律失常和心绞痛方面具有用途。
• US5198449A
  申请人：——

  公开号：US5198449A

  公开（公告）日：1993-03-30
• [1-[3-(Phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones, a novel class of long-acting neuroleptic agents
  作者：Robert F. Boswell、William J. Welstead、Robert L. Duncan、David N. Johnson、William H. Funderburk

  DOI：10.1021/jm00199a029

  日期：1978.1

  In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as the end points. Most compounds were shown to be potent neuroleptic agents and two were found to possess a long duration of action.