(3R)-3-[[(9H-芴-9-甲氧基)羰基]氨基]-5-己酸 | 332064-94-5

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 其他氨基酸衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: (3R)-3-[[(9H-芴-9-甲氧基)羰基]氨基]-5-己酸
• 英文名称: Fmoc-(R)-3-Amino-5-hexynoic acid
• 英文别名: (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-ynoic acid
• CAS: 332064-94-5
• 化学式: C₂₁H₁₉NO₄
• 分子量: 349.4
• InChiKey: ALHPEVGGGAQSCG-CQSZACIVSA-N

物化性质

• 熔点：
  152-153℃
• 沸点：
  591.5±50.0 °C(Predicted)
• 密度：
  1.265±0.06 g/cm3 (20 ºC 760 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P362,P403+P233,P501
• 危险性描述：
  H315,H319,H335

文献信息

• PROTEOGLYCAN-BINDING PEPTIDES THAT MODULATE STEM CELL BEHAVIOR
  申请人：Murphy William L.

  公开号：US20110269231A1

  公开（公告）日：2011-11-03

  Biomaterials presenting synthetic peptides and methods of preparing biomaterials are disclosed. More particularly, the disclosure is directed to biomaterials including a substrate including a synthetic peptide thereon, wherein the synthetic peptide is selected from synthetic proteoglycan-binding peptides, synthetic glycosaminoglycan-binding peptides, and combinations thereof. The present disclosure is further directed to methods of preparing the biomaterials for use in sequestering endogenous proteoglycans and endogenous glycosaminoglycans, increasing stem cell proliferation, reducing spontaneous stem cell differentiation, and enhancing induced osteogenic differentiation of mesenchymal stem cells.