(3aS,6S)-6,7-二甲氧基-2,2,4-三甲基-4,6,7,7a-四氢-3aH-[1,3]二噁唑并[4,5-c]吡喃 | 769067-34-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (3aS,6S)-6,7-二甲氧基-2,2,4-三甲基-4,6,7,7a-四氢-3aH-[1,3]二噁唑并[4,5-c]吡喃
• 英文名称: 2-Deoxystreptamin
• 英文别名: 4,6-Diaminocyclohexane-1,2,3-triol
• CAS: 769067-34-7
• 化学式: C₆H₁₄N₂O₃
• 分子量: 162.189
• InChiKey: DTFAJAKTSMLKAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• NEW EFFECTIVE AMINOGLYCOSIDE ANTIBIOTIC FOR MULTIDRUG-RESISTANT BACTERIA
  申请人：Microbial Chemistry Research Foundation

  公开号：EP3498723A1

  公开（公告）日：2019-06-19

  A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.

  本发明公开了一种由以下通式（I）代表的化合物或其药学上可接受的盐或溶液及其药物组合物，以及用其预防或治疗传染性疾病的方法和使用这些方案预防或治疗传染性疾病的方法。式（I）代表的化合物对革兰氏阳性菌和革兰氏阴性菌都具有抗菌活性，可用于预防或治疗由这些细菌引起的传染性疾病。
• Molecules which Bind to the Dimerization Initiation Site (DIS) of HIV RNA, Their Synthesis and Their Applications as Drugs
  申请人：Pale Patrick

  公开号：US20110118202A1

  公开（公告）日：2011-05-19

  The dimerization of HIV RNA is a key step in the virus replication cycle. Based on RNA DIS crystal structures, a novel kind of compounds, dimeric or not, based on neamine was designed and synthesized. Biological studies showed that such compounds bind and interfere with the targeted RNA sequence, opening a new anti-HIV approach. The crystal structures and bio-chemical experiments showed that the DIS of HIV-1 genomic RNA is a target for new anti-HIV drugs and that those drugs could be derived from aminoglycosides. The results revealed that binding of aminoglycosides to the DIS is specific regarding both the aminoglycoside family and the RNA subtype.
• MODULAR SYNTHESIS OF AMINOGLYCOSIDES
  申请人：REVAGENIX, INC.

  公开号：US20220411456A1

  公开（公告）日：2022-12-29

  The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.
• US4340715A
  申请人：——

  公开号：US4340715A

  公开（公告）日：1982-07-20
• US4366302A
  申请人：——

  公开号：US4366302A

  公开（公告）日：1982-12-28