己酸癸酯 | 52363-43-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 己酸癸酯
• 中文别名: 1H-吲唑-3-甲腈,6-氟-
• 英文名称: decyl hexanoate
• 英文别名: hexanoic acid decyl ester；Hexansaeure-decylester
• CAS: 52363-43-6
• 化学式: C₁₆H₃₂O₂
• 分子量: 256.429
• InChiKey: QNKHVQVPARQEKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  183-184 °C(Press: 21-22 Torr)
• 密度：
  0.8610 g/cm3(Temp: 40.4 °C)
• LogP：
  6.899 (est)
• 保留指数：
  1765

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  己酸癸酯 、 ((6-bromohexyl)oxy)dimethylsilane 在 BrF(F₃s)₂ borane 作用下， 以 甲苯 为溶剂， 以70 %的产率得到6-Bromohexoxy-(1-decoxyhexoxy)-dimethylsilane
  参考文献：
  名称：

  [EN] IONIZABLE CATIONIC LIPIDS INCORPORATING SILICON
  [FR] LIPIDES CATIONIQUES IONISABLES COMPRENANT DU SILICIUM

  摘要：

  The invention relates to a novel ionizable cationic lipid family incorporating silicon, which belongs to the trademark LipexSil™ 1st generation lipids wherein at least one of the two side chains contains silyl acetal linker. Lipids containing silyl acetal linker(s) so far are unprecedented in the art and are effective as ionizable cationic lipids in the formulation of empty or loaded lipid nanoparticles (LNPs). The novel linkers according to the invention are designed by means of borane catalysts [WO 2022/129966]. The invention describes the synthesis of the lipids of formula (I), formation and characterization of nanoparticles and biological experiments demonstrating that the lipid nanoparticles prepared with these novel lipids can efficiently deliver their cargo (e.g. RNA, DNA, mRNA, siRNA, pDNA, circular DNA, small biologically active molecules) into the cells.

  公开号：

  WO2024023174A2
• 作为产物：
  描述：

  三丁基硼 、 decyl 2,2-dichloroacetate 在 N,N-二甲基乙酰胺 、 四丁基溴化铵 作用下， 以 四氢呋喃 为溶剂， 以62%的产率得到己酸癸酯
  参考文献：
  名称：

  三烷基硼烷到多卤代化合物的电化学烷基转移反应

  摘要：

  通过使用牺牲阳极工艺，在温和的电解条件下还原二氯乙酸和三氯乙酸癸酯，可得到α-氯碳阴离子，其易于与三烷基硼烷反应，在一步反应中得到烷基化的产物。

  DOI：

  10.1016/j.jorganchem.2006.03.030

文献信息

• [EN] PROCESSES FOR PRODUCING CARBOXYLIC ACIDS<br/>[FR] PROCÉDÉS DE PRODUCTION D'ACIDES CARBOXYLIQUES
  申请人：EASTMAN CHEM CO

  公开号：WO2020205348A1

  公开（公告）日：2020-10-08

  Processes are disclosed for preparing carboxylic acids from organic esters, the processes comprising contacting an ester with water in the presence of an acid catalyst and a homogenizing solvent at conditions effective to form a carboxylic acid. The homogenizing solvent is present in an amount sufficient to form a single-phase reaction mixture comprising the ester, water, and homogenizing solvent. The homogenizing solvent may be selected from acetonitrile, dimethyl sulfoxide, and 1,4-dioxane.

  公开了从有机酯制备羧酸的过程，该过程包括在酸催化剂和均相溶剂存在下将酯与水接触，以形成羧酸的有效条件。均相溶剂以足够量存在，以形成包括酯、水和均相溶剂的单相反应混合物。均相溶剂可以选择自乙腈、二甲基亚砜和1,4-二氧六环。
• Process for preparing solid titanium trichloride useful for the polymerization of an alpha-olefin
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0099026A2

  公开（公告）日：1984-01-25

  A process for preparing solid titanium trichloride useful for the polymerization of an a-olefin, which comprises precipitating violet-colored fine solid particles of titanium trichloride at a temperature of not higher than 150°C from a liquid of titanium trichloride liquefied in the presence of an ether, characterized in that after the amount of the precipitated violet-colored fine solid particles of titanium trichloride reaches at least 80% based on the total amount of titanium trichloride in the system, titanium tetrachloride is added in an amount within a molar ratio of from 0.2 to 10 based on the total amount of titanium trichloride in the system, followed by ageing at a temperature of from 60 to 120°C.

  一种用于聚合 a-烯烃的固体三氯化钛的制备方法，包括在不高于 150℃的温度下，从在醚存在下液化的三氯化钛液体中析出紫色细固体三氯化钛颗粒、其特征在于，当沉淀的三氯化钛紫罗兰色细固体颗粒的量达到体系中三氯化钛总量的至少 80% 时，加入四氯化钛，加入量的摩尔比为 0.2 至 10 的摩尔比加入四氯化钛，然后在 60 至 120°C 的温度下老化。
• Coating varnish composition and antifouling coating composition
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP0711813A2

  公开（公告）日：1996-05-15

  A coating varnish composition comprising a biodegradable polymer (A) comprising one or more kinds of constituent units (b) represented by the general formula (I), (II) or (III) and one or more other kinds of constituent units (a) capable of imparting bio-degradability: wherein in the formula (I), R¹ and R are independently a hydrogen atom, a chlorine atom, a bromine atom, a methyl group, an ethyl group or a phenyl group; in the formula (II), R³ and R⁴ are independently a hydrogen atom, a chlorine atom, a bromine atom, or a substituted or unsubstituted methyl or ethyl group; in the formula (III), R⁵ and R⁶ are independently a hydrogen atom, a methyl group or an ethyl group, and R⁷ is a straight, branched or cyclic alkyl group, an aryl group, a heterocyclic group or an aralkyl group, which may have one or more substituents.

  一种涂料清漆组合物，包含一种可生物降解聚合物 (A)，该聚合物包含一种或多种由通式 (I)、(II) 或 (III) 表示的组成单元 (b) 和一种或多种可赋予生物降解性的其他组成单元 (a)： 其中，在式 (I) 中，R¹ 和 R 独立地为氢原子、氯原子、溴原子、甲基、乙基或苯基；在式 (II) 中，R³ 和 R⁴ 独立地为氢原子、氯原子、溴原子或取代或未取代的甲基或乙基；在式 (III) 中，R⁵ 和 R⁶ 独立地是氢原子、甲基或乙基，R⁷ 是直链、支链或环状烷基、芳基、杂环基或芳烷基，它们可以有一个或多个取代基。
• OIL-BASED INKJET INK
  申请人：Riso Kagaku Corporation

  公开号：EP3945119A1

  公开（公告）日：2022-02-02

  An oil-based inkjet ink is disclosed, that contains a pigment, a fatty acid ester-based solvent (A) having a viscosity of 5.0 mPa·s or lower and a boiling point of 300°C or higher but lower than 400°C, and a fatty acid ester-based solvent (B) having a viscosity of 10.0 mPa·s or higher and a boiling point of 400°C or higher.

  本发明公开了一种油基喷墨墨水，它包含颜料、粘度为 5.0 mPa-s 或更低且沸点为 300°C 或更高但低于 400°C 的脂肪酸酯基溶剂 (A) 以及粘度为 10.0 mPa-s 或更高且沸点为 400°C 或更高的脂肪酸酯基溶剂 (B)。
• Ruhoff; Reid, Journal of the American Chemical Society, 1933, vol. 55, p. 3827
  作者：Ruhoff、Reid

  DOI：——

  日期：——