[EN] SUBSTITUTED BICYCLIC PYRIMIDINE-BASED COMPOUNDS AND COMPOSITIONS AND USES THEREOF [FR] COMPOSÉS BICYCLIQUES SUBSTITUÉS À BASE DE PYRIMIDINE, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
A compound having a KHK inhibitory effect, or pharmaceutically acceptable salts thereof, and use thereof in the preparation of a medicament for treating a disease associated with KHK kinase abnormal expression. Provided is a compound as represented by formula (III) or a pharmaceutically acceptable salt thereof.
Convenient Synthesis of 5,7-Dichlorothiazolo[5,4-d]pyrimidine
作者:Lianhe Shu、Lady Mae Alabanza、Chen Gu
DOI:10.3987/com-12-12499
日期:——
A convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine is reported. The condensation of ethyl isocyanoacetate and ethoxycarbonyl isothiocyanate selectively gave the key 5-aminothiazole intermediate in high yield under mild conditions. This intermediate was then converted to the target product in three steps.
[EN] PURINES AND METHODS OF THEIR USE<br/>[FR] PURINES ET LEURS PROCÉDÉS D'UTILISATION
申请人:[en]KINETA, INC.
公开号:WO2023107552A2
公开(公告)日:2023-06-15
Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.