2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
• 化学式: C₁₅H₁₁N₅O₂
• 分子量: 293.28
• InChiKey: KPXBQGWDYQPKJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Adenosine a2s receptor antagonists for treating restless legs syndrome or related disorders
  申请人：Kase Hiroshi

  公开号：US20050245545A1

  公开（公告）日：2005-11-03

  The present invention provides methods of treating restless legs syndrome or related disorders, comprising administering an effective amount of at least one adenosine A 2A receptor antagonist to a patient in need thereof. More preferably the adenosine A 2A receptor antagonist is a xanthine derivative or a pharmaceutically acceptable salt thereof.

  本发明提供了治疗不安腿综合征或相关疾病的方法，包括施用有效量的至少一种腺苷 A 2A 受体拮抗剂。更优选的是腺苷 A 2A 受体拮抗剂是黄嘌呤衍生物或其药学上可接受的盐。
• ADENOSINE A2A RECEPTOR ANTAGONISTS FOR TREATING RESTLESS LEGS SYNDROME OR NOCTURNAL MYOCLONUS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1534289B1

  公开（公告）日：2008-07-09
• Method of treating an anxiety disorder
  申请人：Kase Hiroshi

  公开号：US20060281770A1

  公开（公告）日：2006-12-14

  Anxiety disorders, such as panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, post-traumatic stress disorder, generalized anxiety disorder, specific phobia, or the like, are treated by administering an effective amount of at least one adenosine A 2A receptor antagonist to a patient in need thereof, optionally in combination with an anxiolytic(s) other than the adenosine A 2A receptor antagonist.
• METHOD OF TREATING AN ANXIETY DISORDER
  申请人：Kase Hiroshi

  公开号：US20120232089A1

  公开（公告）日：2012-09-13

  Anxiety disorders, such as panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, post-traumatic stress disorder, generalized anxiety disorder, specific phobia, or the like, are treated by administering an effective amount of at least one adenosine A 2A receptor antagonist to a patient in need thereof, optionally in combination with an anxiolytic(s) other than the adenosine A 2A receptor antagonist.
• US7759355B2
  申请人：——

  公开号：US7759355B2

  公开（公告）日：2010-07-20