(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[4-methyl-3-[(4-methylphenyl)methyl]phenyl]oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[4-methyl-3-[(4-methylphenyl)methyl]phenyl]oxane-3,4,5-triol
• 化学式: C₂₁H₂₆O₅
• 分子量: 358.4
• InChiKey: OBXAZADHQRSWBQ-ADAARDCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Methods for preventing and treating neurodegenerative disorders
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2382972A1

  公开（公告）日：2011-11-02

  The present invention relates to a method for treating, preventing or slowing, delaying or reversing progression of one or more neurodegenerative disorders in a patient in need thereof characterized by administering a glucopyranosyl-substituted benzene derivative, a tautomer, stereoisomer, mixture or salt thereof, as defined in claim 1 to the patient in need thereof.

  本发明涉及一种治疗、预防或减缓、延迟或逆转有需要的患者的一种或多种神经退行性疾病进展的方法，其特征在于向有需要的患者施用权利要求1中定义的葡萄糖吡喃糖基取代的苯衍生物、其同分异构体、立体异构体、混合物或盐。
• GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1828216B1

  公开（公告）日：2008-09-10
• GLUCOPYRANOSYL-SUBSTITUTED (HETEROARYLOXY-BENZYL)-BENZENE DERIVATIVES AS SGLT INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1874787B1

  公开（公告）日：2009-12-30
• USES OF DPP-IV INHIBITORS
  申请人：DUGI Klaus

  公开号：US20070281940A1

  公开（公告）日：2007-12-06

  The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.
• METHODS FOR PREVENTING AND TREATING NEURODEGENERATIVE DISORDERS
  申请人：Wienrich Marion

  公开号：US20100081625A1

  公开（公告）日：2010-04-01

  The present invention relates to a method for treating, preventing or slowing, delaying or reversing progression of one or more neurodegenerative disorders in a patient in need thereof characterized by administering a glucopyranosyl-substituted benzene derivative, a tautomer, stereoisomer, mixture or salt thereof, as defined in claim 1 to the patient in need thereof.