2,3-dihydroxy-5-methyl-3-[[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methoxycarbonyl]hexanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dihydroxy-5-methyl-3-[[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methoxycarbonyl]hexanoic acid
• 化学式: C₂₁H₃₀O₁₂
• 分子量: 474.5
• InChiKey: RNPNWXZHTQBCSB-HASLYLMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  203
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP1582209B1

  公开（公告）日：2012-09-19
• Use of derivatives of succinate esters for the treatment of dementia
  申请人：Zhang Jianjun

  公开号：US20060281692A1

  公开（公告）日：2006-12-14

  The use of extract form Wangla ( coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by β-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.
• US7557089B2
  申请人：——

  公开号：US7557089B2

  公开（公告）日：2009-07-07