1-Methoxy-2-propan-2-ylcyclohexane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methoxy-2-propan-2-ylcyclohexane
• 化学式: C₁₀H₂₀O
• 分子量: 156.26
• InChiKey: TYAINCVWFIUMCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• TYK2 INHIBITORS AND USES THEREOF
  申请人：Nimbus Lakshmi, Inc.

  公开号：US20190031664A1

  公开（公告）日：2019-01-31

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

  本发明提供了化合物、其组合物以及使用这些化合物来抑制TYK2以及治疗TYK2介导的疾病的方法。
• Hepatitis C inhibitor peptide analogs
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20040224900A1

  公开（公告）日：2004-11-11

  Compounds of formula (I): 1 wherein B, Y, R 3 , R 24 , R 2 , R 1 and R C are defined herein. The compounds are useful as inhibitors of HCV NS3 protease.

  式（I）的化合物：其中B、Y、R3、R24、R2、R1和Rc在此处被定义。这些化合物可用作HCV NS3蛋白酶的抑制剂。
• Hepatitis C inhibitor compound
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20040229818A1

  公开（公告）日：2004-11-18

  Compounds of formula (I): 1 wherein B, X, R 3 , R 21 , R 22 , R 1 and R c are defined herein. The compounds are useful as inhibitors of HCV NS3 protease.

  式（I）的化合物：其中B、X、R3、R21、R22、R1和R在此处定义。这些化合物可用作HCV NS3蛋白酶的抑制剂。
• Hepatitis C Inhibitor Compounds
  申请人：LLINAS-BRUNET Montse

  公开号：US20070243166A1

  公开（公告）日：2007-10-18

  Compounds of formula (I): wherein B, X, R 3 , L 0 , L 1 , L 2 , R 2 , R 1 and R C are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.

  式(I)的化合物：其中B、X、R3、L0、L1、L2、R2、R1和RC的定义如下。该化合物可用作HCV NS3蛋白酶的抑制剂，用于治疗丙型肝炎病毒感染。
• Modulators of peroxisome proliferator activated receptors
  申请人：Brooks Alisa Dawn

  公开号：US20070276138A1

  公开（公告）日：2007-11-29

  Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH 2 — or —CH 2 CH 2 —; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R 1 and W. R 1 is —(CH 2 ) n —CH(OR 2 )—(CH 2 ) m E, —(CH)═C(OR 2 )—(CH 2 ) m E, —(CH 2 ) n —CH(Y)—(CH 2 ) m E or —(CH)═C(Y)—(CH 2 ) m E; wherein E is COOR 3 , C 1 -C 3 -alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C 1 -C 6 alkyl, haloalkyl and aryl-C 0-4 -alkyl; R 2 is —H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR 4 , —COOR 4 , —CONR 5 R 6 , —C(S)R 4 , —C(S)OR 4 or —C(S)NR 5 R 6 . R 3 is —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is —O—, —CH 2 —, —CH 2 CH 2 — or —CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R 1 . R 4 -R 6 are independently —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

  公开了一种化合物，其结构式表示为（I）：其中Ar是取代或未取代的芳香族基团。Q是共价键，-CH2-或-CH2CH2-；W是取代或未取代的烷基或取代或未取代的异烷基连接基团，长度为两到十个原子，优选长度为两到七个原子。苯环A可以选择性地用最多四个取代基取代R1和W。R1是-(CH2)n-CH(OR2)-(CH2)mE，-(CH)=C(OR2)-(CH2)mE，-(CH2)n-CH(Y)-(CH2)mE或-(CH)=C(Y)-(CH2)mE；其中E是COOR3，C1-C3-烷基腈，羧酰胺，磺酰胺，酰基磺酰胺或四唑，其中磺酰胺，酰基磺酰胺和四唑可以选择性地用一个或多个取代基取代，独立地选自C1-C6烷基，卤代烷基和芳基-C0-4-烷基；R2是-H，一种脂肪基，一种取代的脂肪基，卤代烷基，一种芳香基，一种取代的芳香基，-COR4，-COOR4，-CONR5R6，-C（S）R4，-C（S）OR4或-C（S）NR5R6；R3是-H，一种脂肪基，一种取代的脂肪基，一种芳香基或一种取代的芳香基；Y是-O-，-CH2-，-CH2CH2-或-CH═CH-，并与苯环A中与R1正交的碳原子键合；R4-R6独立地是-H，一种脂肪基，一种取代的脂肪基，一种芳香基或一种取代的芳香基；n和m独立地为0、1或2。