(Z)-1-(5-(t-butyl)-1,3,4-oxadiazol-2-yl)-3-methyl-2-(methoxyimino)butan-1-one | 353238-29-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-1-(5-(t-butyl)-1,3,4-oxadiazol-2-yl)-3-methyl-2-(methoxyimino)butan-1-one
• 英文别名: (E)-1-(5-(t-Butyl)-1,3,4-oxadiazol-2-yl)-3-methyl-2-(methoxyimino)butan-1-one；(2Z)-1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-methoxyimino-3-methylbutan-1-one
• CAS: 353238-29-6
• 化学式: C₁₂H₁₉N₃O₃
• 分子量: 253.301
• InChiKey: UAHHAAQSKHKNPN-NVNXTCNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  77.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 1,3,4-oxadiazole derivatives and process for producing the same
  申请人：——

  公开号：US20030130326A1

  公开（公告）日：2003-07-10

  A process for the preparation of compounds represented by formulae (I) and (IV): 1 (wherein symbols in the formulae are described in the description) and the novel 1,3,4-oxadiazole derivative compound represented by formula (I). According to the present invention, preparation of intermediates (compounds of formula (IV)) of 1,3,4-oxadiazole derivatives useful as pharmaceuticals (elastase inhibitors) can be prepared efficiently via novel synthesis intermediates (compounds of formula (I)).

  一种制备式(I)和式(IV)所代表化合物的方法：1（其中式中的符号在说明中描述），以及式(I)所代表的新型1,3,4-噁二唑衍生物化合物。根据本发明，可以通过新型合成中间体(式(I)化合物)高效地制备用于制药(弹性酶抑制剂)的1,3,4-噁二唑衍生物的中间体(式(IV)化合物)。
• 1,3,4-OXADIAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1253144A1

  公开（公告）日：2002-10-30

  A process for the preparation of compounds represented by formulae (I) and (IV): (wherein symbols in the formulae are described in the description) and the novel 1,3,4-oxadiazole derivative compound represented by formula (I). According to the present invention, preparation of intermediates (compounds of formula (IV)) of 1,3,4-oxadiazole derivatives useful as pharmaceuticals (elastase inhibitors) can be prepared efficiently via novel synthesis intermediates (compounds of formula (I)).

  一种制备式(I)和(IV)所代表化合物的工艺： (式中的符号已在描述中说明）和式（I）代表的新型 1,3,4-噁二唑衍生物化合物的制备方法。根据本发明，可通过新型合成中间体（式（I）化合物）高效制备用作药物（弹性蛋白酶抑制剂）的 1,3,4-噁二唑衍生物中间体（式（IV）化合物）。