2-(4,5-Dimethyl-1,3-thiazol-3-ium-3-yl)-1-thiophen-2-ylethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4,5-Dimethyl-1,3-thiazol-3-ium-3-yl)-1-thiophen-2-ylethanone
• 化学式: C11H12NOS2+
• 分子量: 238.4
• InChiKey: DDTLCHVGIIPVPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
  申请人：——

  公开号：US20020182165A1

  公开（公告）日：2002-12-05

  A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula 1

  一种用于改善生物力学和扩散特性的头发、指甲、离体器官、离体细胞或离体组织的治疗方法和组合物，包括有效量的来自化合物公式1所述化合物组合的化合物。
• Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds
  申请人：——

  公开号：US20030176417A1

  公开（公告）日：2003-09-18

  The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

  本发明涉及用于逆转高级糖基化终产物介导的交联和蛋白质老化的组合物和方法。因此，本发明描述了含有被杂环基取代的噻唑化合物的组合物，这些化合物能够逆转高级糖基化终产物交联的形成。本发明揭示了该发明的工业和治疗应用，因为食品变质和动物蛋白质老化可以得到治疗。这些化合物在治疗蛋白质老化方面具有特殊应用，如对与衰老和糖尿病并发症有关的蛋白质老化的治疗。
• REVERSING ADVANCED GLYCOSYLATION CROSS-LINKS USING HETEROCYCLIC-SUBSTITUTED THIAZOLIUM SALTS
  申请人：Alteon, Inc.

  公开号：EP1128830A1

  公开（公告）日：2001-09-05
• EP1128830A4
  申请人：——

  公开号：EP1128830A4

  公开（公告）日：2004-03-31
• JP2002529414A
  申请人：——

  公开号：JP2002529414A

  公开（公告）日：2002-09-10