[5-(2-fluoro-pyridin-4-yl)-4-(3-methoxyphenyl)-1,3-thiazol-2-yl]amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [5-(2-fluoro-pyridin-4-yl)-4-(3-methoxyphenyl)-1,3-thiazol-2-yl]amine
• 英文别名: [5-(2-fluoro-4-pyridyl)-4-(3-methoxyphenyl)-1,3-thiazol-2-yl]amine；5-(2-Fluoropyridin-4-yl)-4-(3-methoxyphenyl)-1,3-thiazol-2-amine
• 化学式: C₁₅H₁₂FN₃OS
• 分子量: 301.344
• InChiKey: SMBJDVRJQDZFBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  89.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [5-(2-fluoro-pyridin-4-yl)-4-(3-methoxyphenyl)-1,3-thiazol-2-yl]amine 、 苄胺 生成 N-[4-[2-amino-4-(3-methoxyphenyl)-1,3-thiazol-5-yl]-2-pyridyl]-N-benzylamine
  参考文献：
  名称：

  5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1180518B1
• 作为产物：
  描述：

  2-(2-氟吡啶-4-基)-1-(3-甲氧基苯基)乙酮 、 硫脲 在 溴 、 三乙胺 作用下， 生成 [5-(2-fluoro-pyridin-4-yl)-4-(3-methoxyphenyl)-1,3-thiazol-2-yl]amine
  参考文献：
  名称：

  5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1180518B1

文献信息

• Substituted 1,3-thiazole compounds, their production and use
  申请人：——

  公开号：US20040053973A1

  公开（公告）日：2004-03-18

  (1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

  (1) 一种1,3-噻唑化合物，其5位被取代为含有一个取代基的4-吡啶基团，该取代基不包括芳香基，或者(2) 一种1,3-噻唑化合物，其5位被取代为一个吡啶基团，该吡啶基团的氮原子邻近位置有一个取代基，该取代基不包括芳香基，具有出色的p38 MAP激酶抑制活性。
• 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
  申请人：Ohkawa Shigenori

  公开号：US20060135566A1

  公开（公告）日：2006-06-22

  An optionally N-oxidized compound represented by the formula: wherein R 1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R 2 represents an aromatic group, R 3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR 4 (R 4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A 3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A 3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.

  一种可选氧化的化合物，其化学式表示为：其中R1代表氢、烃基、杂环、氨基、酰基，R2代表芳香基团，R3代表氢、吡啶基、芳香烃基，X代表氧、可选氧化硫，Y代表键、氧、可选氧化硫、由公式NR4（R4代表氢、烃基或酰基）表示的基团，Z代表键或二价非环烷基，或其盐具有出色的腺苷A3受体拮抗活性，并用作预防或治疗与腺苷A3受体相关的疾病的药物。此外，化合物(I)或其盐具有p38 MAP激酶抑制活性和TNF-α抑制活性，并用作预防或治疗与p38 MAP激酶相关的疾病和与TNF-α相关的疾病的药物。
• 5-pyridyl-1, 3-azole compounds, process for producing the same and use there of
  申请人：Ohkawa Shigenori

  公开号：US20090048307A1

  公开（公告）日：2009-02-19

  An optionally N-oxidized compound represented by the formula: wherein R 1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R 2 represents an aromatic group, R 3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR 4 (R 4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A 3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A 3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.

  一种可选择氧化的化合物，其化学式表示为：其中R1表示氢，碳氢化合物，杂环，氨基，酰基，R2表示芳香基团，R3表示氢，吡啶基，芳香烃，X表示氧，可选择氧化的硫，Y表示键，氧，可选择氧化的硫，一个由公式NR4（R4表示氢，碳氢化合物或酰基）表示的基团和Z表示键或二价无环碳氢化合物，或其盐具有出色的腺苷A3受体拮抗活性，并用作预防或治疗与腺苷A3受体相关的疾病的药剂。此外，该化合物（I）或其盐具有p38 MAP激酶抑制活性和TNF-α抑制活性，并用作预防或治疗与p38 MAP激酶和TNF-α相关的疾病的药剂。
• [EN] SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE<br/>[FR] COMPOSES DE 1,3-THIAZOLE SUBSTITUES, PRODUCTION ET UTILISATION DESDITS COMPOSES
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2001074811A2

  公开（公告）日：2001-10-11

  (1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

  (1) 一种1,3-噻唑化合物，其中5位被一个带有不包括芳香族的取代基的4-吡啶基取代，或者(2)一种1,3-噻唑化合物，其中5位被一个在吡啶基的氮原子邻近位置带有不包括芳香族的取代基的吡啶基取代。这类化合物展现出优异的p38丝裂原活化蛋白激酶抑制活性。
• SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1268474A2

  公开（公告）日：2003-01-02