2,11-Dioxododecanedial

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,11-Dioxododecanedial
• 化学式: C₁₂H₁₈O₄
• 分子量: 226.27
• InChiKey: RKLAYSZHSASJHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Anticancer agents based on prevention of protein prenylation
  申请人：The Arizona Disease Control Research Commission

  公开号：US20030219847A1

  公开（公告）日：2003-11-27

  Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. &agr;-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.

  前酰化酶参与修饰 RAS 等肿瘤蛋白，从而使肿瘤细胞的生长失控。二羰基化合物可用于共价修饰，从而使蛋白质法尼基转移酶和蛋白质香叶基转移酶等前酰化酶失活。化合物的设计可以增强对特定蛋白质底物的亲和力和/或特异性。
• US7344851B2
  申请人：——

  公开号：US7344851B2

  公开（公告）日：2008-03-18
• [EN] ANTICANCER AGENTS BASED ON PREVENTION OF PROTEIN PRENYLATION<br/>[FR] AGENTS ANTICANCEREUX REPOSANT SUR LA PREVENTION DE LA PRENYLATION DE PROTEINES
  申请人：ARIZONA DISEASE CONTROL RESEAR

  公开号：WO2000033826A1

  公开（公告）日：2000-06-15

  Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. α-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.