(E)-3-菲-2-基丙-2-烯酸 | 7470-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: (E)-3-菲-2-基丙-2-烯酸
• 英文名称: 3t-(phenanthryl-(2))-acrylic acid
• 英文别名: 3t-(Phenanthryl-(2))-acrylsaeure；2-Phenanthreneacrylic acid；(E)-3-phenanthren-2-ylprop-2-enoic acid
• CAS: 7470-20-4
• 化学式: C₁₇H₁₂O₂
• 分子量: 248.281
• InChiKey: YEEMGQYDLFLFDX-UXBLZVDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  (E)-3-菲-2-基丙-2-烯酸 在 乙醇 、 铂 作用下， 生成 3-[2]菲基-丙酸
  参考文献：
  名称：

  Personality disorders and psychoses form two distinct subgroups of homicide among female offenders

  摘要：

  This study examined circumstances of homicide by women in relation to their subsequent diagnoses. We investigated the written reports of forensic psychiatric examinations on 125 Finnish women who committed murder, attempted murder, manslaughter, or attempted manslaughter during 1982-92. In 86% of the cases the victims were adults, in 15% children. Intimate partners were the victims in 54% of the cases. Stabbing was the most frequent method and a quarrel the most frequent motive. The diagnoses of personality disorders and psychoses formed distinct subgroups. Psychotic women attacked proportionally more children than the personality disordered, who mainly attacked adults. Personality disordered women were more likely to have been intoxicated with alcohol at the time. Future treatment programmes and studies are suggested.

  DOI：

  10.1080/09585180122116
• 作为产物：
  描述：

  丙二酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 生成 (E)-3-菲-2-基丙-2-烯酸
  参考文献：
  名称：

  Phenanthrene Derivatives. VII. The Cyclization of β-Phenanthrylpropionic Acids

  摘要：

  DOI：

  10.1021/ja01290a034

文献信息

• Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships
  作者：James B. Summers、Ki H. Kim、Hormoz Mazdiyasni、James H. Holms、James D. Ratajczyk、Andrew O. Stewart、Richard D. Dyer、George W. Carter

  DOI：10.1021/jm00165a017

  日期：1990.3

  An evaluation of the quantitative structure-activity relationships (QSAR) for more than 100 hydroxamic acids revealed that the primary physicochemical feature influencing the in vitro 5-lipoxygenase inhibitory potencies of these compounds is the hydrophobicity of the molecule. A significant correlation was observed between the octanol-water partition coefficient of the substituent attached to the carbonyl of the hydroxamate and in vitro inhibitory activity. This correlation held for hydroxamic acids of diverse structure and with potencies spanning 4 orders of magnitude. Although the hydrophobicity may be packaged in a variety of structural ways and still correlate with potency, the QSAR study revealed two major exceptions. Specifically, the hydrophobicity of portions of compounds in the immediate vicinity of the hydroxamic acid functionality does not appear to contribute to increased inhibition and the hydrophobicity of fragments beyond approximately 12 A from the hydroxamate do not influence potency. The QSAR study also demonstrated that inhibitory activity was enhanced when there was an alkyl group on the hydroxamate nitrogen, when electron-withdrawing substituents were present and when the hydroxamate was conjugated to an aromatic system. These observations provide a simple description of the lipoxygenase-hydroxamic acid binding site.
• US3987116A
  申请人：——

  公开号：US3987116A

  公开（公告）日：1976-10-19
• Personality disorders and psychoses form two distinct subgroups of homicide among female offenders
  作者：Hanna Putkonen、Jutta Collander、Marja-Liisa Honkasalo、Jouko Lönnqvist

  DOI：10.1080/09585180122116

  日期：2001.1

  This study examined circumstances of homicide by women in relation to their subsequent diagnoses. We investigated the written reports of forensic psychiatric examinations on 125 Finnish women who committed murder, attempted murder, manslaughter, or attempted manslaughter during 1982-92. In 86% of the cases the victims were adults, in 15% children. Intimate partners were the victims in 54% of the cases. Stabbing was the most frequent method and a quarrel the most frequent motive. The diagnoses of personality disorders and psychoses formed distinct subgroups. Psychotic women attacked proportionally more children than the personality disordered, who mainly attacked adults. Personality disordered women were more likely to have been intoxicated with alcohol at the time. Future treatment programmes and studies are suggested.
• Phenanthrene Derivatives. VII. The Cyclization of β-Phenanthrylpropionic Acids
  作者：W. E. Bachmann、M. C. Kloetzel

  DOI：10.1021/ja01290a034

  日期：1937.11