(E)-4-(4-氯-2-丁烯氧基)苯甲醛 | 959773-31-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: (E)-4-(4-氯-2-丁烯氧基)苯甲醛
• 英文名称: (E)-4-(4-chloro-2-butenyloxy)benzaldehyde
• 英文别名: 4-[(E)-4-chlorobut-2-enoxy]benzaldehyde
• CAS: 959773-31-0
• 化学式: C₁₁H₁₁ClO₂
• 分子量: 210.66
• InChiKey: RCAZMZZOPZDGCX-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-4-(4-氯-2-丁烯氧基)苯甲醛 、 N-benzyl-D-gluconamide 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以56.1%的产率得到(2R,3S,4R,5R)-N-benzyl-2-[(E)-4-(4-formylphenoxy)but-2-enoxy]-3,4,5,6-tetrahydroxyhexanamide
  参考文献：
  名称：

  Synthesis of crosslinked nanostructured saccharidic vinyl copolymers and their functionalization

  摘要：

  Saccharidic monomers and a macromonomer were synthesized and copolymerized in the presence of divinylbenzene (DVB) as crosslinker in conditions of separation of phases to give hydrophilic nanostructured sugar-based vinyl copolymers. Appropriate model molecules such as N-benzyl-D-gluconamide for the saccharidic copolymers and 4-(4-chlorobutoxy) benzaldehyde and (E)-4-(4-chloro-2-butenyloxy) benzaldehyde for electrophilic reagents prefiguring possible copper amine oxidase inhibitors allowed identification of conditions for useful monofunctionalizations mainly at the position 2 of the saccharidic units. The examined samples of the nanostructured copolymers from one of the monomers proved to be stable enough to tolerate the functionalization reactions without loss of morphology. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.08.106
• 作为产物：
  描述：

  (E)-4-(4-hydroxy-2-butenyloxy)benzaldehyde 在 2,4,6-三甲基吡啶 、 甲基磺酰氯 、 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.5h， 以83%的产率得到(E)-4-(4-氯-2-丁烯氧基)苯甲醛
  参考文献：
  名称：

  Synthesis of crosslinked nanostructured saccharidic vinyl copolymers and their functionalization

  摘要：

  Saccharidic monomers and a macromonomer were synthesized and copolymerized in the presence of divinylbenzene (DVB) as crosslinker in conditions of separation of phases to give hydrophilic nanostructured sugar-based vinyl copolymers. Appropriate model molecules such as N-benzyl-D-gluconamide for the saccharidic copolymers and 4-(4-chlorobutoxy) benzaldehyde and (E)-4-(4-chloro-2-butenyloxy) benzaldehyde for electrophilic reagents prefiguring possible copper amine oxidase inhibitors allowed identification of conditions for useful monofunctionalizations mainly at the position 2 of the saccharidic units. The examined samples of the nanostructured copolymers from one of the monomers proved to be stable enough to tolerate the functionalization reactions without loss of morphology. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.08.106

文献信息

• Nanostructured styrenic co-polymers containing glucopyranosyl residues and their functionalization
  作者：Marco Pocci、Silvana Alfei、Francesco Lucchesini、Vincenzo Bertini、Barbara Idini

  DOI：10.1016/j.tet.2009.05.033

  日期：2009.7

  Sugar-based co-polymers with saccharidic units in stable cyclic form and nanometric morphologies stabilized through crosslinking, adaptable through specific functionalizations to biochemical interaction studies with copper-containing amine oxidases, were synthesized from appropriate monomers and macromonomers. The most promising nanospherical co-polymer obtained, containing beta-D-glucopyranosidic units, was employed in functionalization reactions with the help of model molecules, achieving useful transformations mainly at the 6-position and to a minor extent at the 2-position of the saccharidic system. (C) 2009 Elsevier Ltd. All rights reserved.
• Synthesis of crosslinked nanostructured saccharidic vinyl copolymers and their functionalization
  作者：Vincenzo Bertini、Marco Pocci、Silvana Alfei、Barbara Idini、Francesco Lucchesini

  DOI：10.1016/j.tet.2007.08.106

  日期：2007.11

  Saccharidic monomers and a macromonomer were synthesized and copolymerized in the presence of divinylbenzene (DVB) as crosslinker in conditions of separation of phases to give hydrophilic nanostructured sugar-based vinyl copolymers. Appropriate model molecules such as N-benzyl-D-gluconamide for the saccharidic copolymers and 4-(4-chlorobutoxy) benzaldehyde and (E)-4-(4-chloro-2-butenyloxy) benzaldehyde for electrophilic reagents prefiguring possible copper amine oxidase inhibitors allowed identification of conditions for useful monofunctionalizations mainly at the position 2 of the saccharidic units. The examined samples of the nanostructured copolymers from one of the monomers proved to be stable enough to tolerate the functionalization reactions without loss of morphology. (c) 2007 Elsevier Ltd. All rights reserved.