3-[(2-Methyl-2-undecyl-1,3-dioxolan-4-yl)methoxy]propane-1-sulfonic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[(2-Methyl-2-undecyl-1,3-dioxolan-4-yl)methoxy]propane-1-sulfonic acid
• 化学式: C₁₉H₃₈O₆S
• 分子量: 394.6
• InChiKey: RIXGSYSJYLZYED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Destructible surfactants and uses thereof
  申请人：Lee Jeng Jong Peter

  公开号：US20080027234A1

  公开（公告）日：2008-01-31

  Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group which enables the surfactant to be broken down under acidic conditions. The invention also includes methods of making anionic surfactants and methods of using anionic surfactants in a variety of applications.

  本发明提供了可破坏性表面活性剂及其使用方法。本发明包括带有二氧兰或二氧杂环官能团的阴离子表面活性剂，该官能团使得表面活性剂能够在酸性条件下被分解。本发明还包括制备阴离子表面活性剂的方法以及在各种应用中使用阴离子表面活性剂的方法。
• ACID LABILE SURFACTANTS
  申请人：Waters Technologies Corporation

  公开号：US20190263774A1

  公开（公告）日：2019-08-29

  This invention relates to an acid labile surfactant. In particular, the surfactants of the present invention include a dioxolane or dioxane functional group which enables the surfactant to hydrolyze in an acidic environment. Surfactants of this type can be utilized to enhance protein solubilization/enzyme digestion. Following hydrolysis to destroy the surfactant (which may chromatographic issues), there are generally two components formed—a hydrophilic one, and a hydrophobic one. By altering the chemistry of the hydrolysable linker, the polarity of the hydrophobic residue can be altered, allowing it to be solubilized by significantly less organic solvent, and to minimize the potential loss of peptide material and to expand the chromatographic conditions that can be utilized.

  本发明涉及一种酸敏感表面活性剂。特别地，本发明的表面活性剂包括二氧兰或二氧杂环功能基团，使得表面活性剂能够在酸性环境下水解。这种类型的表面活性剂可用于增强蛋白质溶解/酶消化。在水解后破坏表面活性剂（可能会产生色谱问题）后，通常会形成两个组分 - 一个亲水性的组分和一个疏水性的组分。通过改变可水解连接剂的化学性质，可以改变疏水性残基的极性，使其能够被较少的有机溶剂溶解，并最小化肽材料的潜在损失，并扩展可利用的色谱条件。
• DESTRUCTIBLE SURFACTANTS AND USES THEREOF
  申请人：Waters Technologies Corporation

  公开号：US20140065651A1

  公开（公告）日：2014-03-06

  The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

  本发明提供了一种使用可破坏表面活性剂增强分子化学反应（例如生物分子）。这些化学反应可能涉及和/或与分析相关，例如溶解、分离、纯化和/或表征分子。在一方面，本发明的阴离子表面活性剂可以在相对较低的pH值下被选择性地分解。表面活性剂的分解产物可以相对容易地从分子/样品中去除。该发明适用于各种分析技术。
• Method of serum pre-treatment for glycomic analysis
  申请人：Nishimura Shin-Ichiro

  公开号：US20090187011A1

  公开（公告）日：2009-07-23

  A means for pre-treatment in glycomic analysis of a glycoprotein is provided by the present invention. A salt of the general formula (I): wherein Z, X, R 1 , R 2 , M, m and n are the same as described in DESCRIPTION, is useful as a protein solubilizer, and an oligosaccharide is efficiently released from a sample if reductive alkylation and/or digestion by a proteinase are carried out under the presence of the said solubilizer at the first step in the glycomic analysis of glycoprotein derived from a living body.

  本发明提供了一种糖蛋白质糖组学分析的预处理手段。通式（I）的盐在蛋白质溶解剂方面具有用途，如果在糖蛋白质的糖组学分析的第一步中，在所述溶解剂的存在下进行还原烷基化和/或蛋白酶消化，则样品中的寡糖可以高效地释放，其中Z、X、R1、R2、M、m和n如描述中所述。
• Acid labile surfactants
  申请人：Waters Technologies Corporation

  公开号：US10822323B2

  公开（公告）日：2020-11-03

  This invention relates to an acid labile surfactant. In particular, the surfactants of the present invention include a dioxolane or dioxane functional group which enables the surfactant to hydrolyze in an acidic environment. Surfactants of this type can be utilized to enhance protein solubilization/enzyme digestion. Following hydrolysis to destroy the surfactant (which may chromatographic issues), there are generally two components formed—a hydrophilic one, and a hydrophobic one. By altering the chemistry of the hydrolysable linker, the polarity of the hydrophobic residue can be altered, allowing it to be solubilized by significantly less organic solvent, and to minimize the potential loss of peptide material and to expand the chromatographic conditions that can be utilized.

  本发明涉及一种酸性表面活性剂。特别是，本发明的表面活性剂含有二氧戊环或二氧六环官能团，可使表面活性剂在酸性环境中水解。这类表面活性剂可用于提高蛋白质的溶解度/酶消化率。水解破坏表面活性剂后（可能会产生色谱问题），通常会形成两种成分--亲水性成分和疏水性成分。通过改变可水解连接体的化学性质，可改变疏水残留物的极性，从而大大减少有机溶剂对其的增溶作用，最大限度地减少肽材料的潜在损失，并扩大可使用的色谱条件。