(R)-(-)-2-甲氧基丙酸乙酯 | 40105-20-2

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-(-)-2-甲氧基丙酸乙酯
• 英文名称: (2R)-Ethyl 2-methoxypropanoate
• 英文别名: ethyl-(R)-2-methoxypropionate；d(+)-α-methoxy-propionic acid ethyl ester；d(+)-α-Methoxy-propionsaeure-aethylester；α-Methoxy-propionsaeure-aethylester；ethyl (R)-(-)-2-methoxypropionate；ethyl(R)-(-)-2-methoxypropionate；(R)-ethyl 2-methoxypropanoate；ethyl (2R)-2-methoxypropanoate
• CAS: 40105-20-2
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: WHRLOJCOIKOQGL-RXMQYKEDSA-N

物化性质

• 沸点：
  160.0±13.0 °C(Predicted)
• 密度：
  0.959±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  (R)-(-)-2-甲氧基丙酸乙酯 在 lithium aluminium tetrahydride 、 氢氧化钾 、 水 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以60%的产率得到(R)+ 2-甲氧在-1-丙醇
  参考文献：
  名称：

  Pyranouidole Derivatives and the Use Thereof for the Treatment of Hepatitis C Virus Infection or Disease

  摘要：

  这项发明涉及新型吡喃吲哚衍生物和类似物，以及含有这些物质的组合物，以及将其用于治疗、预防或抑制由丙型肝炎病毒引起的病毒感染和相关疾病的用途。

  公开号：

  US20070219212A1
• 作为产物：
  描述：

  重氮甲烷 、 D-乳酸乙酯 在 tetrafluoroboric acid 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 (R)-(-)-2-甲氧基丙酸乙酯
  参考文献：
  名称：

  On enantioselective separation of phenoxypropionates using permethylated β-cyclodextrin HPLC and GC columns

  摘要：

  Investigations on chiral phenoxypropionates using permethylated beta-cyclodextrin HPLC and GC columns showed a decrease in enantioselective separation efficiency from mecoprop-methyl and dichlorprop-methyl to the threefold chlorinated fenoprop-methyl. This corresponded to decreasing electron density in the aromatic system due to the increasing negative inductive effect of 3 chlorine substituents. Investigation on methyl-(RS)2-(2,4-dichloro-3,6-dinitrophenoxy)-propionate confirmed the influence of electrophilic substituents while determination of ethyl-(RS)-2-methoxypropionate emphasized the necessity of an aromatic system for enantioselective separation on beta-cyclodextrin stationary phases. For fenoprop-methyl as well as for the aryloxyphenoxypropionates diclofop-methyl and fluazifop-butyl, reversed phase HPLC showed higher separation performance than high resolution capillary GC. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0045-6535(97)00134-3

文献信息

• [EN] PROSTACYCLIN DERIVATIVES<br/>[FR] DÉRIVÉS DE PROSTACYCLINE
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2011003058A1

  公开（公告）日：2011-01-06

  This invention relates to novel prostacyclin derivatives and acceptable salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by prostacyclin, and in particular those diseases and conditions beneficially treated by dilators of systemic and pulmonary arterial vascular beds or by platelet aggregation inhibitors.

  本发明涉及新的前列腺素I2衍生物及其可接受的盐。该发明还提供了包含本发明化合物的组合物，以及将这些组合物用于治疗通过前列腺素I2有益治疗的疾病和状况的方法，特别是那些通过全身和肺动脉血管床扩张剂或通过血小板聚集抑制剂有益治疗的疾病和状况。
• Phosphane ligands with two binding sites of differing hardness for enantioselective Grignard cross coupling
  作者：Andreas Terfort、Henri Brunner

  DOI：10.1039/p19960001467

  日期：——

  A series of new, chiral phosphanes is presented, individual members of which were designed to serve as ligands in transition-metal mediated asymmetric Grignard cross coupling reactions. These ligands are characterized by a side chain containing one or two oxygen atoms with the capacity to act as binding sites for the incoming Grignard reagent. A number of structural parameters for the compounds was varied to learn about the reaction mechanism. Most of the ligands were tested in two cross coupling reactions, the formation of 3-phenylbut-1-ene and of 2,2′-dimethyl-1,1′-binaphthyl, respectively. Although both systems gave modest enantiomeric excesses it was not possible to make a comparison of their respective abilities.

  一系列新型手性膦被呈现出来，其中每个成员都被设计为在过渡金属介导的不对称Grignard交叉偶联反应中作为配体。这些配体的特点是具有含一个或两个氧原子的侧链，它们具备作为进入的Grignard试剂结合位点的能力。研究中改变了许多化合物的结构参数以深入了解反应机理。多数配体在两种交叉偶联反应中进行了测试，分别用于生成3-苯基丁-1-烯和2,2′-二甲基-1,1′-联萘。虽然这两个系统都获得了适度的对映体过量，但无法对其各自的能力进行比较。
• Enantioselective cyclopropane syntheses using the chiral carbene complexes (SFe)- and (RFe)-C5H5(CO)(PR3)Fe:CHCH3+. A mechanistic analysis of the carbene transfer reaction
  作者：Maurice Brookhart、Yumin Liu、Emma W. Goldman、Debra A. Timmers、Gregory D. Williams

  DOI：10.1021/ja00003a028

  日期：1991.1

  ethylidene transfer from these complexes to styrene, vinyl acetate, and isopropenyl acetate gave methylcyclopropanes in high optical yields. A mechanistic analysis of the transfer reaction is presented by using the stereochemical results obtained coupled with deuterium labeling and relative reactivity studies. It is concluded that the most likely mechanism for carbene transfer involves reaction of the

  通过使用标准技术将对映体纯的酰基配合物转化为相应的对映体纯的卡宾配合物(S Fe )-和(R Fe )-C 5 H 5 (CO)(PR 3 )Fe=CHCH 3 + 。对映选择性亚乙基从这些配合物转移到苯乙烯、乙酸乙烯酯和乙酸异丙烯酯，得到高光学产率的甲基环丙烷。通过使用获得的立体化学结果以及氘标记和相对反应性研究，对转移反应进行了机理分析。得出的结论是，卡宾转移的最可能机制涉及烯烃与 C 5 H 5 (CO)(PR 3 )Fe=CHCH 3 + 的次要但更具反应性的向斜异构体的反应，然后是发展中的亲电子中心的背面攻击在 Fe-Cα 键上的 Cγ。
• PROSTACYCLIN DERIVATIVES
  申请人：Masse Craig E.

  公开号：US20120270934A1

  公开（公告）日：2012-10-25

  This invention relates to novel prostacyclin derivatives and acceptable salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by prostacyclin, and in particular those diseases and conditions beneficially treated by dilators of systemic and pulmonary arterial vascular beds or by platelet aggregation inhibitors.

  本发明涉及新颖的前列环素衍生物及其可接受的盐。本发明还提供了包含本发明化合物的组合物，并使用这些组合物在治疗利于前列环素治疗的疾病和病况的方法中，特别是那些通过扩张系统和肺动脉血管床或通过抑制血小板聚集而有益地治疗的疾病和病况。
• Freudenberg; Markert, Chemische Berichte, 1927, vol. 60, p. 2447
  作者：Freudenberg、Markert

  DOI：——

  日期：——