N,N'-bis[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]decane-1,10-disulfonamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N,N'-bis[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]decane-1,10-disulfonamide
• 化学式: C₇₀H₁₀₂N₄O₁₀S₂
• 分子量: 1223.7
• InChiKey: BXAZYCGIJPUXJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.8
• 重原子数：
  86
• 可旋转键数：
  47
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  195
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES
  申请人：Advanced Medicine, Inc.

  公开号：EP1086063A1

  公开（公告）日：2001-03-28
• EP1086063A4
  申请人：——

  公开号：EP1086063A4

  公开（公告）日：2001-03-28
• [EN] NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES<br/>[FR] MEDICAMENTS A CANAL POTASSIUM ET LEUR UTILISATION
  申请人：ADVANCED MEDICINE INC

  公开号：WO1999064050A1

  公开（公告）日：1999-12-16

  This invention relates to novel multibinding compounds that bind to potassium (K+) channels and modulate their activity. The compounds of this invention comprise 2-10 K+ channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of K+ channel. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to the K+ channel. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by K+ channels. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.