N-glucopyranosyl alendronate | 349102-40-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-glucopyranosyl alendronate
• 英文别名: [1-hydroxy-1-phosphono-4-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]butyl]phosphonic acid
• CAS: 349102-40-5
• 化学式: C₁₀H₂₃NO₁₂P₂
• 分子量: 411.24
• InChiKey: NRKMRJFOHQTIPP-LOFWALOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.2
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  238
• 氢给体数：
  10
• 氢受体数：
  13

文献信息

• Novel bisphosphonates and uses thereof
  申请人：——

  公开号：US20020002140A1

  公开（公告）日：2002-01-03

  Glycosides and orthoester glyco side derivatives of bisphosphonate compounds useful for treating and/or preventing hypercalcaemia of malignancy, Paget's disease, osteoporosis, metastatic cancer in bone and soft tissue and periodontal disease have markedly enhanced intestinal absorption and enhanced bioavailability.

  糖苷和正酯糖苷衍生物是双磷酸盐化合物的衍生物，可用于治疗和/或预防恶性高钙血症、帕吉特病、骨质疏松症、骨和软组织的转移性癌症以及牙周病，具有明显增强的肠道吸收和生物利用度。
• [EN] NOVEL BISPHOSPHONATES AND USES THEREOF<br/>[FR] NOUVEAUX BISPHOSPHONATES ET LEURS UTILISATIONS
  申请人：STRAKAN GROUP PLC

  公开号：WO2001051497A1

  公开（公告）日：2001-07-19

  Glycosides and orthoester glycoside derivatives of bisphosphonate compounds useful for treating and/or preventing hypercalcaemia of malignancy, Paget's disease, osteoporosis, metastatic cancer in bone and soft tissue and periodontal disease have markedly enhanced intestinal absorption and enhanced bioavailability.