(R)-4-苄基哌嗪-2-羧酸 | 137442-19-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-4-苄基哌嗪-2-羧酸
• 英文名称: (R)-4-Benzyl-piperazine-2-carboxylic acid
• 英文别名: (R)-4-benzylpiperazine-2-carboxylic acid；(2R)-4-benzylpiperazine-2-carboxylic acid
• CAS: 137442-19-4
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: RBMNCOYMAYDTOP-LLVKDONJSA-N

物化性质

• 沸点：
  389.0±42.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  (R)-4-苄基哌嗪-2-羧酸 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 作用下， 以 四氢呋喃 为溶剂， 生成 (R)-2-(tert-butyldimethylsiloxy)methylpiperazine
  参考文献：
  名称：

  Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions

  摘要：

  Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01031-x
• 作为产物：
  描述：

  氯化苄 、 (R)-piperazine-2-carboxylic acid dihydrochloride 在 TEA 作用下， 以78%的产率得到(R)-4-苄基哌嗪-2-羧酸
  参考文献：
  名称：

  Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions

  摘要：

  Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01031-x

文献信息

• CLEANING COMPOSITION AND METHOD OF MANUFACTURING METAL WIRING USING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20150136728A1

  公开（公告）日：2015-05-21

  A cleaning composition includes about 0.01 to about 5 wt % of a chelating agent; about 0.01 to about 0.5 wt % of an organic acid; about 0.01 to about 1.0 wt % of an inorganic acid; about 0.01 to about 5 wt % of an alkali compound; and deionized water.
• US9340759B2
  申请人：——

  公开号：US9340759B2

  公开（公告）日：2016-05-17
• US9869027B2
  申请人：——

  公开号：US9869027B2

  公开（公告）日：2018-01-16
• Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions
  作者：Tsutomu Inoue、Daisuke Sato、Kenichi Komura、Shinichi Itsuno

  DOI：10.1016/s0040-4039(99)01031-x

  日期：1999.7

  Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand. (C) 1999 Elsevier Science Ltd. All rights reserved.