Butyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]pyridin-1-ium-3-carboxylate;bromide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Butyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]pyridin-1-ium-3-carboxylate;bromide
• 化学式: C18H18BrCl2NO3
• 分子量: 447.1
• InChiKey: HEBZOWPEXHXCJQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.12
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  47.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP1304101A1

  公开（公告）日：2003-04-23

  The invention discloses a new class of compounds particularly pyridinium derivatives, which have been found to exhibit triple function of a free radical scavenger (antioxidant), AGE breaker and AGE inhibitor, and cosmetic composition comprising these compounds contained in a cosmetically acceptable carrier. The invention also discloses a method of cosmetic application by applying such composition. The invention further discloses a pharmaceutical composition, comprising said compounds useful in scavenging free radicals from the body cells of a mammal, a method of scavenging free radicals from the body cells of a mammal and a method of treating of diseases caused by accumulation of free radicals in the body cells of a mammal by administering a composition made with the compounds of the invention. The invention in addition, also discloses composition and method for inhibiting AGE in a mammal by use of the compounds of the same group.

  本发明公开了一类新化合物，特别是吡啶鎓衍生物，它们被发现具有自由基清除剂（抗氧化剂）、AGE 破坏剂和 AGE 抑制剂的三重功能，还公开了包含在化妆品可接受载体中的这些化合物的化妆品组合物。本发明还公开了一种通过施用此类组合物进行美容的方法。本发明进一步公开了一种药物组合物，其中包含有助于清除哺乳动物体细胞中自由基的所述化合物；一种清除哺乳动物体细胞中自由基的方法；以及一种通过施用用本发明化合物制成的组合物治疗哺乳动物体细胞中自由基积累引起的疾病的方法。此外，本发明还公开了通过使用同组化合物抑制哺乳动物体内 AGE 的组合物和方法。