methyl 2-acetamido-2-deoxy-4-O-(3-[4-methoxy-2,3,5 ,6-tetrafluorobenzamido]-3-deoxy-β-D-galactopyranosyl)-β-D-glucopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-acetamido-2-deoxy-4-O-(3-[4-methoxy-2,3,5 ,6-tetrafluorobenzamido]-3-deoxy-β-D-galactopyranosyl)-β-D-glucopyranoside
• 英文别名: N-[(2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]-2,3,5,6-tetrafluoro-4-methoxybenzamide
• 化学式: C₂₃H₃₀F₄N₂O₁₂
• 分子量: 602.491
• InChiKey: SGIMAQIHRYNHIZ-HLKZTURFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  206
• 氢给体数：
  7
• 氢受体数：
  16

文献信息

• Inhibitors against galectins
  申请人：——

  公开号：US20040147730A1

  公开（公告）日：2004-07-29

  The present invention relates to novel compounds, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal. Said galectin is preferably a galectin 3.

  本发明涉及新型化合物，所述化合物的用途为药物，并用于制造治疗哺乳动物中与galectin与受体结合有关的疾病的药物。所述galectin优选为galectin 3。
• Immunomodulating compositions and uses therefor
  申请人：Ralph, Stephen John

  公开号：EP2591786A1

  公开（公告）日：2013-05-15

  The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.

  本发明公开了免疫调节组合物。更具体地说，本发明公开了包含免疫调节剂和凝集素活性剂的组合物，这些组合物有助于刺激和延长宿主免疫细胞反应。本发明的组合物特别适用于治疗和/或预防一系列疾病，包括病原体感染、自身免疫性疾病、移植排斥反应、移植物抗宿主疾病、过敏、炎症性疾病以及癌症和肿瘤。
• Immunomodulating Compositions and uses Therefor
  申请人：Ralph John Stephen

  公开号：US20070207161A1

  公开（公告）日：2007-09-06

  The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
• IMMUNOMODULATING COMPOSITIONS AND USES THEREFOR
  申请人：Ralph Stephen John

  公开号：US20150265701A1

  公开（公告）日：2015-09-24

  The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
• Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor
  申请人：TUFTS UNIVERSITY

  公开号：US20150320782A1

  公开（公告）日：2015-11-12

  Methods and kits using a pharmaceutical composition for use in inhibiting ocular angiogenesis or fibrosis are provided herein, such that composition includes a pharmaceutically suitable carrier or diluent and an amount of the inhibitor composition effective to inhibit the angiogenesis or the fibrosis by inhibiting expression and/or activity of a galectin protein or a portion thereof.