inosine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: inosine
• 英文别名: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4,5-dihydro-1H-purin-6-one
• 化学式: C₁₀H₁₄N₄O₅
• 分子量: 270.245
• InChiKey: REAFDQSBEQBZSJ-LDGWMWDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  inosine 在 三氯氧磷 、 水 作用下， 反应 0.1h， 以75%的产率得到inosine 5′-monophosphate
  参考文献：
  名称：

  Fully Automated Continuous Meso-flow Synthesis of 5′-Nucleotides and Deoxynucleotides

  摘要：

  The first continuous meso-flow synthesis of natural and non-natural 5'-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

  DOI：

  10.1021/op5002066

文献信息

• Fully Automated Continuous Meso-flow Synthesis of 5′-Nucleotides and Deoxynucleotides
  作者：Chenjie Zhu、Chenglun Tang、Zhi Cao、Wei He、Yong Chen、Xiaochun Chen、Kai Guo、Hanjie Ying

  DOI：10.1021/op5002066

  日期：2014.11.21

  The first continuous meso-flow synthesis of natural and non-natural 5'-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.