(S)-4-(2-苯基乙酰氧基)苄基-2-氨基-3-苯基丙酸酯 | 330970-64-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (S)-4-(2-苯基乙酰氧基)苄基-2-氨基-3-苯基丙酸酯
• 英文名称: [4-(2-phenylacetyl)oxyphenyl]methyl (2S)-2-amino-3-phenylpropanoate
• CAS: 330970-64-4
• 化学式: C₂₄H₂₃NO₄
• 分子量: 389.451
• InChiKey: CDONLEZHFUGVLJ-QFIPXVFZSA-N

物化性质

• 沸点：
  556.2±50.0 °C(Predicted)
• 密度：
  1.210±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-4-(2-苯基乙酰氧基)苄基-2-氨基-3-苯基丙酸酯 在 青霉素(酰胺)酶 、 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 甲醇 、 phosphate buffer 为溶剂， 生成 对羟基苯甲醇
  参考文献：
  名称：

  Synthesis and Membrane-Binding Properties of a Characteristic Lipopeptide from the Membrane-Anchoring Domain of Influenza Virus A Hemagglutinin

  摘要：

  On the trail of the influenza virus! Fluorescent-labeled lipopeptides, such as the characteristic S-palmitoylated partial structure from influenza virus hemagglutinin A, can be synthesized efficiently by employing a new enzymatic protecting-group technique in the key steps. Their binding to model membranes was determined in a kinetic assay, so leading to a first approximation of the membrane-anchoring ability of the corresponding lipopeptide motif in the parent protein.

  DOI：

  10.1002/1521-3773(20010119)40:2<369::aid-anie369>3.0.co;2-7
• 作为产物：
  描述：

  BOC-L-苯丙氨酸 、 4-(hydroxymethyl)phenyl 2-phenylacetate 在 4-二甲氨基吡啶 、 达卡巴嗪 、 盐酸 作用下， 以 乙醚 为溶剂， 生成 (S)-4-(2-苯基乙酰氧基)苄基-2-氨基-3-苯基丙酸酯
  参考文献：
  名称：

  Synthesis and Membrane-Binding Properties of a Characteristic Lipopeptide from the Membrane-Anchoring Domain of Influenza Virus A Hemagglutinin

  摘要：

  On the trail of the influenza virus! Fluorescent-labeled lipopeptides, such as the characteristic S-palmitoylated partial structure from influenza virus hemagglutinin A, can be synthesized efficiently by employing a new enzymatic protecting-group technique in the key steps. Their binding to model membranes was determined in a kinetic assay, so leading to a first approximation of the membrane-anchoring ability of the corresponding lipopeptide motif in the parent protein.

  DOI：

  10.1002/1521-3773(20010119)40:2<369::aid-anie369>3.0.co;2-7

文献信息

• Synthesis and Membrane-Binding Properties of a Characteristic Lipopeptide from the Membrane-Anchoring Domain of Influenza Virus A Hemagglutinin
  作者：Frank Eisele、Jürgen Kuhlmann、Herbert Waldmann

  DOI：10.1002/1521-3773(20010119)40:2<369::aid-anie369>3.0.co;2-7

  日期：2001.1.19

  On the trail of the influenza virus! Fluorescent-labeled lipopeptides, such as the characteristic S-palmitoylated partial structure from influenza virus hemagglutinin A, can be synthesized efficiently by employing a new enzymatic protecting-group technique in the key steps. Their binding to model membranes was determined in a kinetic assay, so leading to a first approximation of the membrane-anchoring ability of the corresponding lipopeptide motif in the parent protein.