2,3-dihydroxybutanedioic acid;N-methyl-N-prop-2-enylprop-2-en-1-amine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dihydroxybutanedioic acid;N-methyl-N-prop-2-enylprop-2-en-1-amine
• 化学式: C11H19NO6
• 分子量: 261.27
• InChiKey: CBFIBZPZPCWDAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.83
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• FAT-BINDING POLYMERS, OPTIONALLY COMBINED WITH LIPASE INHIBITORS
  申请人：Geltex Pharmaceuticals, Inc.

  公开号：EP1196181A1

  公开（公告）日：2002-04-17
• US6299868B1
  申请人：——

  公开号：US6299868B1

  公开（公告）日：2001-10-09
• US7048917B1
  申请人：——

  公开号：US7048917B1

  公开（公告）日：2006-05-23
• [EN] FAT-BINDING POLYMERS, OPTIONALLY COMBINED WITH CIPASE INHIBITORS<br/>[FR] POLYMERES FIXANT LA GRAISSE, COMBINES EVENTUELLEMENT AVEC DES INHIBITEURS DE LIPASE
  申请人：GELTEX PHARMA INC

  公开号：WO2001005408A1

  公开（公告）日：2001-01-25

  The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.