2-(4-Acetylpiperazin-1-yl)-1-(4-fluorophenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-Acetylpiperazin-1-yl)-1-(4-fluorophenyl)ethanone
• 化学式: C₁₄H₁₇FN₂O₂
• mdl: MFCD12564751
• 分子量: 264.29
• InChiKey: KYZSYVPAWAANOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• AGENT FOR EXPRESSION OF LONG-TERM POTENTIATION OF SYNAPTIC TRANSMISSION COMPRISING COMPOUND HAVING BRAIN SOMATOSTATIN ACTIVATION PROPERTY
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1235575A2

  公开（公告）日：2002-09-04
• [EN] AGENT FOR EXPRESSION OF LONG-TERM POTENTIATION OF SYNAPTIC TRANSMISSION COMPRISING COMPOUND HAVING BRAIN SOMATOSTATIN ACTIVATION PROPERTY<br/>[FR] AGENT POUR L'EXPRESSION DE LA POTENTIALISATION A LONG TERME DE LA TRANSMISSION SYNAPTIQUE, COMPRENANT UN COMPOSE POSSEDANT LA PROPRIETE D'ACTIVER LA SOMATOSTATINE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000072834A2

  公开（公告）日：2000-12-07

  The present invention relates to an agent for the expression of long-term potentiation of synaptic transmission, which contains a compound having a brain somatostatin activation property as an active ingredient and to a screening method of an agent for the expression of long-term potentiation of synaptic transmission, which uses a somatostatin releasing property as an index. The present invention is useful for the prophylaxis and/or treatment of cerebral diseases of dementia, amnesia, manic-depressive psychosis, schizophrenia, Parkinson's disease, psychosomatic disease and the like.