(Z)-10-羟基-2-癸烯酸 | 131532-29-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: (Z)-10-羟基-2-癸烯酸
• 英文名称: cis-10-Hydroxy-2-decensaeure
• 英文别名: cis-10-Hydroxy-dec-2-ensaeure；cis-10-Hydroxy-dec-2-en-1-saeure；10-hydroxy-2Z-decenoic acid；(Z)-10-hydroxydec-2-enoic acid
• CAS: 131532-29-1
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.251
• InChiKey: QHBZHVUGQROELI-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-Hydroxy-decin-(2)-saeure-(1) 在 Lindlar's catalyst 喹啉 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 生成 (Z)-10-羟基-2-癸烯酸
  参考文献：
  名称：

  的合成反式-10-hydroxydec -2-烯酸和相关化合物

  摘要：

  描述了两种立体异构的10-羟基癸-2-烯酸的合成。的反式-异构体是与来自蜜蜂的蜂王浆分离主脂肪酸相同。

  DOI：

  10.1016/0040-4020(61)80003-3

文献信息

• Methods of treating neurodevelopmental diseases and disorders
  申请人：Deakin University

  公开号：US10251856B2

  公开（公告）日：2019-04-09

  The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-HDA. In particular, the methods of the present invention are useful in the treatment and/or prophylaxis of acquired or progressive neurodevelopmental disorders and conditions in mammals. More particularly, methods are taught herein for the treatment and/or prophylaxis of diseases and disorders such as autism spectrum disorders.

  本发明一般涉及治疗和/或预防神经系统疾病和失调的方法，其中涉及给药反式 10-HDA。特别是，本发明的方法可用于治疗和/或预防哺乳动物获得性或进行性神经发育障碍和病症。更特别的是，本文教导的方法可用于治疗和/或预防自闭症谱系障碍等疾病和紊乱。
• Methods of treating or alleviating mental disorders and associated symptoms
  申请人：The Florey Institute of Neuroscience and Mental Health

  公开号：US11197840B2

  公开（公告）日：2021-12-14

  The present invention relates generally to methods for the treatment and/or prophylaxis of mental illness involving administration of 10-HDA. More particularly, methods are taught herein for the treatment and/or prophylaxis of obsessive compulsive disorder, anxiety disorder or a condition characterised by one or more symptoms of a obsessive compulsive disorder or an anxiety disorder.

  本发明一般涉及施用 10-HDA 治疗和/或预防精神疾病的方法。更具体地说，本发明涉及治疗和/或预防强迫症、焦虑症或以一种或多种强迫症或焦虑症症状为特征的疾病的方法。
• METHODS OF TREATING OR ALLEVIATING MENTAL DISORDERS AND ASSOCIATED SYMPTOMS
  申请人：The Florey Institute of Neuroscience and Mental Health

  公开号：EP3423049A1

  公开（公告）日：2019-01-09
• Methods of Treating Neurodevelopmental Diseases and Disorders
  申请人：Deakin University

  公开号：US20170087110A1

  公开（公告）日：2017-03-30

  The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-HDA. In particular, the methods of the present invention are useful in the treatment and/or prophylaxis of acquired or progressive neurodevelopmental disorders and conditions in mammals. More particularly, methods are taught herein for the treatment and/or prophylaxis of diseases and disorders such as autism spectrum disorders.
• Methods of Treating or Alleviating Mental Disorders and Associated Symtoms
  申请人：The Florey Institute of Neuroscience and Mental Health

  公开号：US20180353452A1

  公开（公告）日：2018-12-13

  The present invention relates generally to methods for the treatment and/or prophylaxis of mental illness involving administration of 10-HDA. More particularly, methods are taught herein for the treatment and/or prophylaxis of obsessive compulsive disorder, anxiety disorder or a condition characterised by one or more symptoms of a obsessive compulsive disorder or an anxiety disorder.