N-[2-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-bromo-6-[(5-chloropyridin-2-yl)carbamoyl]phenyl]-1-propan-2-ylpiperidine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[2-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-bromo-6-[(5-chloropyridin-2-yl)carbamoyl]phenyl]-1-propan-2-ylpiperidine-4-carboxamide
• 化学式: C₂₉H₃₇BrClN₅O₈
• 分子量: 699.0
• InChiKey: DDLWZDOOPRZDPA-GCVKPHKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  183
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• Substituted benzene derivatives or salts thereof
  申请人：——

  公开号：US20040077555A1

  公开（公告）日：2004-04-22

  There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-&bgr;-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-&bgr;-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

  提供了一些化合物，基于抑制激活的血液凝血因子X而具有抗凝作用，并可用作抗凝剂或预防/治疗由血栓形成或栓塞引起的疾病的药物。有效成分包括化合物，如4'-溴-2'-[(5-氯-2-吡啶基)氨基甲酰]-6'-β-D-半乳糖苷氧基-1-异丙基哌啶-4-羧酰胺，2'-（2-乙酰氨基-2-脱氧-β-D-葡萄糖苷氧基）-4'-溴-6'-[(5-氯-2-吡啶基)氨基甲酰]-1-异丙基哌啶-4-羧酰胺等，或其盐。
• SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF
  申请人：Ishihara Tsukasa

  公开号：US20090137498A1

  公开（公告）日：2009-05-28

  There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

  提供了一些化合物，基于抑制活化的血液凝血因子X，具有抗凝作用，并可用作抗凝剂或预防/治疗由血栓形成或栓塞引起的疾病的药物。有效成分是化合物，例如4'-溴-2'-[(5-氯-2-吡啶基)氨基甲酰基]-6'-β-D-半乳糖苷氧基-1-异丙基哌啶-4-羧酰胺，2'-(2-乙酰氨基-2-脱氧-β-D-葡萄糖苷氧基)-4'-溴-6'-[(5-氯-2-吡啶基)氨基甲酰基]-1-异丙基哌啶-4-羧酰胺等或其盐。
• SUBSTITUTED PHENOL DERIVATIVES OR SALTS THEREOF AS INHIBITORS OF COAGULATION FACTOR X
  申请人：Astellas Pharma Inc.

  公开号：EP1336605B1

  公开（公告）日：2006-04-12
• EP1336605A4
  申请人：——

  公开号：EP1336605A4

  公开（公告）日：2004-01-28
• US7504417B2
  申请人：——

  公开号：US7504417B2

  公开（公告）日：2009-03-17