[(2R,3R,4S,5S,6S)-2-(butoxymethyl)-6-methoxy-3,5-diphosphonooxyoxan-4-yl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4S,5S,6S)-2-(butoxymethyl)-6-methoxy-3,5-diphosphonooxyoxan-4-yl] dihydrogen phosphate
• 化学式: C₁₁H₂₅O₁₅P₃
• 分子量: 490.23
• InChiKey: PPDCEIYJUPAMIB-UVOCVTCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  228
• 氢给体数：
  6
• 氢受体数：
  15

文献信息

• The use of growth factor modulation compounds substituted with three vicinal phosphorus containing radical in the manufacture of a medicament for tissue repair
  申请人：PERSTORP AB

  公开号：EP1216705A2

  公开（公告）日：2002-06-26

  The invention relates to the use of a compound containing a high density, negatively charged domain of vicinally oriented radicals for the preparing of a medicament providing a growth factor modulating activity in mammals including man.

  本发明涉及一种含有高密度、带负电荷的邻接基域的化合物，用于制备对哺乳动物（包括人类）具有生长因子调节活性的药物。
• Use of growth factor modulating compounds
  申请人：——

  公开号：US20020065253A1

  公开（公告）日：2002-05-30

  The present invention relates to a method of treating angiogenesis in tumor conditions in a mammal suffering therefrom which comprises administering to a mammal in need thereof an effective amount of a cyclic compound selected from the group consisting of cyclopentane, cyclohexane, cycloheptane, monosaccharide, disaccharide, trisaccharide, tetrasaccharide, piperidine, tetrahydrothiopyran, 5-oxotetrahydrothiopyran, 5,5-dioxotetrahydrothiopyran, tetrahydroselenopyran, tetrahydrofuran, pyrrolidine, tetrahydrothiophene, 5-oxotetrahydrothiophene, 5,5-dioxotetrahydrothiophene, tetrahydroselenophene, benzene, cumene, mesitylene, naphthalene and phenanthrene, in which said cyclic compound is substituted by at least three vicinal phosphorus containing radicals of the formula: 1 The present application is also directed to the use of these compounds for treating inflammatory conditions, tissue repair conditions and/or infectious conditions in a mammal.

  本发明涉及一种治疗患有肿瘤的哺乳动物体内血管生成的方法，该方法包括向有需要的哺乳动物施用有效量的环状化合物，该环状化合物选自由环戊烷、环己烷、环庚烷、单糖、二糖、三糖、四糖、哌啶、四氢噻喃、5-氧代四氢噻喃、5,5-二氧代四氢噻喃、四氢硒喃、四氢呋喃、吡咯烷、四氢苯并呋喃、5-氧代四氢噻喃、四氢噻喃、5-氧代四氢噻喃、5,5-二氧代四氢噻喃、四氢呋喃、吡咯烷、四氢噻吩、5-氧代四氢噻吩、5,5-二氧代四氢噻吩、四氢硒吩、苯、积烯、间苯二酚、萘和菲，其中所述环状化合物至少被三个邻接的含磷基取代，其式如下 1 本申请还涉及使用这些化合物治疗哺乳动物的炎症、组织修复和/或感染性疾病。
• Use of a compound with a negatively charged domain of radicals for the treatment of restenosis
  申请人：——

  公开号：US20040235799A1

  公开（公告）日：2004-11-25

  There is disclosed the use of a compound containing a high density negatively charged domain of vicinally oriented radicals for the preparing of a medicament for preventing, alleviating or combating restenosis in mammals including man.

  本文公开了一种含有高密度带负电荷的沧海基域的化合物，用于制备预防、缓解或抗击哺乳动物（包括人类）血管再狭窄的药物。
• METHOD OF TREATING INFLAMMATORY, TISSUE REPAIR AND INFECTIOUS CONDITIONS
  申请人：Siren Matti

  公开号：US20050227946A1

  公开（公告）日：2005-10-13

  The present invention relates to a method of treating inflammatory, tissue repair and infectious conditions in a mammal suffering therefrom which comprises administering to a mammal in need thereof an effective amount of a cyclic compound selected from the group consisting of cyclopentane, cyclohexane, cycloheptane, monosaccharide. disaccharide, trisaccharide, tetrasaccharide, piperidine, tetrahydrothiopyran, 5-oxotetrahydrothiopyran, 5,5-dioxotetrahydrothiopyran, tetrahydroselenopyran, tetrahydrofuran, pyrrolidine, tetrahydrothiophene, 5-oxotetrahydrothiophene, 5,5-dioxotetrahydrothiophene, tetrahydroselenophene, benzene, cumene, mesitylene, naphthalene and phenanthrene, in which said cyclic compound is substituted by at least three vicinal phosphorus containing radicals of the formula:

  二糖、三糖、四糖、哌啶、四氢噻喃、5-氧代四氢噻喃、5,5-二氧代四氢噻喃、四氢硒喃、四氢呋喃、吡咯烷、四氢噻吩、5-氧代四氢噻吩、5,5-二氧代四氢噻吩、四氢硒吩、苯、积烯、间苯二酚、萘和菲，其中所述环状化合物至少被三个如下式的含磷基取代：
• DERIVATIVES OF CARBOHYDRATES AND COMPOSITIONS CONTAINING THEM
  申请人：PERSTORP AB

  公开号：EP0793668A1

  公开（公告）日：1997-09-10