N-[(3S,15E,19S,21R,24R)-6-chloro-24-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-14-[(2S,4S,5S,6S)-5-(dimethylamino)-4-hydroxy-6-methyloxan-2-yl]oxy-11-oxo-4,12,20-trioxa-7-azapentacyclo[13.6.2.25,8.13,21.019,21]hexacosa-1,5,7,15,25-pentaen-17,22-diyn-10-yl]-3-hydroxy-7,8-dimethoxy-6-propan-2-yloxynaphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(3S,15E,19S,21R,24R)-6-chloro-24-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-14-[(2S,4S,5S,6S)-5-(dimethylamino)-4-hydroxy-6-methyloxan-2-yl]oxy-11-oxo-4,12,20-trioxa-7-azapentacyclo[13.6.2.25,8.13,21.019,21]hexacosa-1,5,7,15,25-pentaen-17,22-diyn-10-yl]-3-hydroxy-7,8-dimethoxy-6-propan-2-yloxynaphthalene-2-carboxamide
• 化学式: C₅₃H₆₀ClN₃O₁₆
• 分子量: 1030.5
• InChiKey: GFTRTMUGNRZABD-ZPJLCGQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  73
• 可旋转键数：
  11
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  239
• 氢给体数：
  5
• 氢受体数：
  18

文献信息

• Erythropoietin: remodeling and glycoconjugation of erythropoietin
  申请人：DeFrees Shawn

  公开号：US20080187955A1

  公开（公告）日：2008-08-07

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Factor VIII: remodeling and glycoconjugation of factor VIII
  申请人：DeFrees Shawn

  公开号：US20100261872A1

  公开（公告）日：2010-10-14

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Factor IX: Remodeling and Glycoconjugation of Factor IX
  申请人：Novo Nordisk A/S

  公开号：US20140170728A1

  公开（公告）日：2014-06-19

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS
  申请人：Novo Nordisk A/S

  公开号：US20140294762A1

  公开（公告）日：2014-10-02

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• MODULAR PROTEIN DRUG CONJUGATE THERAPEUTIC
  申请人：ZYMEWORKS INC.

  公开号：US20160114057A1

  公开（公告）日：2016-04-28

  The invention provides modular antibody-therapeutic agent conjugates and antibody-detectable-agent conjugates, and methods of using said conjugates in therapeutic and diagnostic procedures.