1-Phenacylpyridin-1-ium-2,5-dicarboxylic acid;bromide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Phenacylpyridin-1-ium-2,5-dicarboxylic acid;bromide
• 化学式: C15H12BrNO5
• 分子量: 366.16
• InChiKey: YCBMEFVYPZLUHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.74
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  95.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compounds and compositions for treating tissue ischemia
  申请人：——

  公开号：US20020193412A1

  公开（公告）日：2002-12-19

  There is disclosed a genus of compounds and pharmaceutical compositions that are protective for mitigating damage associated with tissue ischemia, particularly stroke (CNS ischemia), and ischemia of the myocardium. The present invention further provides a method for treating tissue damage caused by ischemia. Lastly, the present invention provides a method for treating tissue damage caused by providing a compound that inhibits the cytotoxic activity of 3-aminopropanal.

  本发明公开了一类化合物和药物组合物，它们对减轻与组织缺血，特别是中风（中枢神经系统缺血）和心肌缺血有关的损伤具有保护作用。本发明进一步提供了一种治疗缺血引起的组织损伤的方法。最后，本发明提供了一种治疗组织损伤的方法，该方法通过提供一种化合物来抑制 3-氨基丙醛的细胞毒性活性。
• COMPOUNDS AND COMPOSITIONS FOR TREATING TISSUE ISCHEMIA
  申请人：THE PICOWER INSTITUTE FOR MEDICAL RESEARCH

  公开号：EP1098647A1

  公开（公告）日：2001-05-16
• EP1098647A4
  申请人：——

  公开号：EP1098647A4

  公开（公告）日：2003-06-18
• US6391899B1
  申请人：——

  公开号：US6391899B1

  公开（公告）日：2002-05-21
• [EN] COMPOUNDS AND COMPOSITIONS FOR TREATING TISSUE ISCHEMIA<br/>[FR] COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE L'ISCHEMIE TISSULAIRE
  申请人：PICOWER INST MED RES

  公开号：WO2000003711A1

  公开（公告）日：2000-01-27

  There is disclosed a genus of compounds and pharmaceutical compositions that are protective for mitigating damage associated with tissue ischemia, particularly stroke (CNS ischemia), and ischemia of the myocardium. The present invention further provides a method for treating tissue damage caused by ischemia. Lastly, the present invention provides a method for treating tissue damage caused by providing a compound that inhibits the cytotoxic activity of 3-aminopropanal.