N'-methylsulfonyl-1-phenacylpyridin-1-ium-3-carbohydrazide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N'-methylsulfonyl-1-phenacylpyridin-1-ium-3-carbohydrazide
• 化学式: C15H16N3O4S+
• 分子量: 334.4
• InChiKey: SGSVRFZYUPDELW-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PYRIDINIUM DERIVATIVES FOR THE MANAGEMENT OF AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP1222171A1

  公开（公告）日：2002-07-17
• [EN] PYRIDINIUM DERIVATIVES FOR THE MANAGEMENT OF AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF<br/>[FR] NOUVEAUX COMPOSES UTILES POUR TRAITER LES COMPLICATIONS VASCULAIRES LIEES A L'AGE ET AU DIABETE, PROCEDE DE PREPARATION ET UTILISATIONS THERAPEUTIQUES DE CES COMPOSES
  申请人：SANKARANARAYANAN ALANGUDI

  公开号：WO2001025208A1

  公开（公告）日：2001-04-12

  The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discoloration of teeth, by breaking preformed AGE, of general formula (I), or pharmaceutically acceptable salts thereof, wherein, R1, R2, R3, X and m are as defined in the specification. The invention also discloses, method for preparation of the novel compounds of the series and pharmaceutical composition having one or more compounds as defined above as active ingredients. The invention further discloses a method of treatment of a diabetic patient by administering the compounds as defined above, either singly or in combination with drugs for antidiabetic therapy.