2-Fluoro-4-(5-isobutoxy-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Fluoro-4-(5-isobutoxy-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonamide
• 英文别名: 2-Fluoro-4-[5-(2-methylpropoxy)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
• 化学式: C₁₄H₁₅F₄N₃O₃S
• 分子量: 381.351
• InChiKey: HKZIXXOLKISKRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Pyrazole ether derivatives as anti-inflammatory/analgesic agents
  申请人：——

  公开号：US20020058681A1

  公开（公告）日：2002-05-16

  The present invention relates to compounds of the formula 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

  本发明涉及公式1中的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、A、X和Y的定义如规范中所述，以及含有它们的药物组合物和它们的药用。本发明的化合物在治疗或缓解炎症和其他与炎症相关的疾病方面具有用处，如关节炎、结肠癌和阿尔茨海默病等哺乳动物，最好是人类、狗、猫和家畜动物。
• PYRAZOLE ETHER DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS
  申请人：Pfizer Products Inc.

  公开号：EP1259504A1

  公开（公告）日：2002-11-27
• US6878726B2
  申请人：——

  公开号：US6878726B2

  公开（公告）日：2005-04-12
• [EN] PYRAZOLE ETHER DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS<br/>[FR] DERIVES D'ETHER DE PYRAZOLE UTILISES COMME AGENTS ANTI-INFLAMMATOIRES/ANALGESIQUES
  申请人：PFIZER PROD INC

  公开号：WO2001064669A1

  公开（公告）日：2001-09-07

  The present invention relates to compounds of formula (I), wherein R?1, R2, R3, R4, R5, R6, R7, R8¿, A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.