申请人:Institute for Cancer Research
公开号:US11077121B2
公开(公告)日:2021-08-03
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
本发明提供了用于诱导表达胸腺嘧啶DNA糖基化酶的癌细胞生长停滞、分化或衰老,并对癌症进行相应治疗的组合物、试剂盒和方法。这些方法包括抑制胸腺嘧啶 DNA 糖基化酶在癌细胞中的表达或生物活性。抑制癌细胞中胸腺嘧啶DNA糖基化酶可诱导细胞恢复到健康的非癌表型和/或诱导细胞衰老。癌细胞包括黑色素瘤、肺癌、前列腺癌、胰腺癌、卵巢癌、脑癌、结肠癌、直肠乙状结肠癌和乳腺癌细胞。