氢醌氢溴酸盐水合物 | 207386-86-5

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 中文名称: 氢醌氢溴酸盐水合物
• 英文名称: (R)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydrate;hydrobromide
• CAS: 207386-86-5
• 化学式: C20H29BrN2O3
• 分子量: 425.4
• InChiKey: IWSVSZYIGVGHCN-HZQSTTLBSA-N

物化性质

• 熔点：
  180-224 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  46.6
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• IDENTIFICATION OF STRUCTURALLY SIMILAR SMALL MOLECULES THAT ENHANCE THERAPEUTIC EXON SKIPPING
  申请人：The Regents of the University of California

  公开号：US20160257952A1

  公开（公告）日：2016-09-08

  This invention relates, e.g., to a method for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with an effective amount of a compound such as, for example, Perphenazine, Flupentixol DiHCl, Zuclopenthixol or Corynanthine HCl, or a compound which shares a similar 2-D structure and activity level with one of these compounds, or a pharmaceutically acceptable salt, hydrate, solvate, or isomer of the compound, and, optionally, with an antisense oligonucleotide that is specific for a splicing sequence in the pre-mRNA Methods for treating Duchenne muscular dystrophy (DMD) are disclosed.

  本发明涉及一种增强感兴趣的前mRNA的外显子跳跃的方法，包括将前mRNA与有效量的化合物接触，例如Perphenazine、Flupentixol DiHCl、Zuclopenthixol或Corynanthine HCl，或具有类似2-D结构和活性水平的化合物，或化合物的药学上可接受的盐，水合物，溶剂化物或异构体，以及选择性针对前mRNA中剪接序列的反义寡核苷酸（如果需要）。还公开了治疗杜氏肌肉萎缩症（DMD）的方法。
• Method of Treating Transplant Rejection and Autoimmune Diseases
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20140050694A1

  公开（公告）日：2014-02-20

  A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of SU-5416 is disclosed.