奎宁磷酸盐 | 549-60-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 中文名称: 奎宁磷酸盐
• 英文名称: (R)-[(2S,4S,5R)-5-Ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;phosphoric acid
• 英文别名: (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;phosphoric acid
• CAS: 549-60-0
• 化学式: C20H27N2O6P
• 分子量: 422.4
• InChiKey: YONMXAODZKOTLR-DSXUQNDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD

  公开号：US20180118658A1

  公开（公告）日：2018-05-03

  The present invention provides a (meth)acrylate manufacturing method characterized in that when manufacturing a (meth) acrylate by an ester exchange reaction between an alcohol and a monofunctional (meth)acrylate using catalyst A and catalyst B together, contact treatment of the ester exchange reaction product with adsorbent C is performed. Catalyst A: One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure and salts or complexes thereof, amidine and salts or complexes thereof, compounds with a pyridine ring and salts or complexes thereof, phosphines and salts or complexes thereof, and compounds with a tertiary diamine structure and salts or complexes thereof. Catalyst B: One or more kinds of compounds selected from a group consisting of compounds comprising zinc. Adsorbent C: One or more kinds of compounds selected from a group consisting of oxides and hydroxides comprising at least one of magnesium, aluminum and silicon.

  本发明提供了一种（甲基）丙烯酸酯制备方法，其特征在于通过在使用催化剂A和催化剂B一起进行醇和单官能基（甲基）丙烯酸酯之间的酯交换反应制备（甲基）丙烯酸酯时，对酯交换反应产物进行与吸附剂C的接触处理。催化剂A：从含有氮杂双环结构的环状三级胺及其盐或络合物、胺嘧啶及其盐或络合物、含有吡啶环的化合物及其盐或络合物、膦及其盐或络合物、以及含有三级二胺结构的化合物及其盐或络合物中选择的一种或多种化合物。催化剂B：从含锌化合物中选择的一种或多种化合物。吸附剂C：从含有镁、铝和硅中至少一种的氧化物和氢氧化物中选择的一种或多种化合物。
• MULTIFUNCTIONAL (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD.

  公开号：US20170204044A1

  公开（公告）日：2017-07-20

  [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

  [问题] 本发明的目的是通过多元醇（如戊三醇或二戊三醇）与单官能基（甲基）丙烯酸酯的酯交换反应，获得产率高的多功能（甲基）丙烯酸酯。[解决方案] 一种多功能（甲基）丙烯酸酯制备方法，其特征在于，在通过多元醇与单官能基（甲基）丙烯酸酯的酯交换反应制备多功能（甲基）丙烯酸酯时，同时使用催化剂（A）和催化剂（B）。催化剂（A）：选自具有氮杂双环结构的环三胺或其盐或络合物、酰胺或其盐或络合物以及吡啶环或其盐或络合物组成的群中的一种或多种化合物。催化剂（B）：选自含锌化合物组成的群中的一种或多种化合物。
• METHOD FOR PRODUCING (METH)ACRYLATE
  申请人：TOAGOSEI CO., LTD.

  公开号：US20180105483A1

  公开（公告）日：2018-04-19

  A method for producing a (meth) acrylate comprises transesterification reaction of an alcohol and a monofunctional (meth) acrylate with catalysts in combination being cyclic tertiary amines having an azabicyclo structure and compounds containing zinc, separating a solid that contains the catalysts from a reaction product containing a (meth) acrylate, and producing a (meth) acrylate by transesterification reaction of an alcohol and a monofunctional (meth) acrylate, while using the recovered solid catalyst.

  生产（甲基）丙烯酸酯的方法包括使用具有氮杂双环结构的环状三级胺和含锌化合物作为催化剂，将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，从含有催化剂的固体中分离出含有（甲基）丙烯酸酯的反应产物，然后通过将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，并使用回收的固体催化剂来生产（甲基）丙烯酸酯。
• INJECTABLE ANTICANCER COMPOSITION FOR LOCAL ADMINISTRATION CONTAINING SUSPENSION OF QUININE SALT
  申请人：Yeo, Oh Young

  公开号：EP3260138A1

  公开（公告）日：2017-12-27

  Disclosed herein is an injectable anticancer composition for local administration, which contains a suspension of quinine hydrochloride. The anticancer composition for local administration according to the present invention shows an IC50 value against MKN-45 cells, which is about 10 times lower than Paclitaxel, as determined by an MTT assay in vitro, suggesting that the anticancer composition has an excellent cytotoxic effect. The anticancer composition can be administered as a safe anticancer agent in clinical applications, and also shows an anticancer effect by inducing the necrosis and detachment of solid cancer cells. Particularly, the anticancer composition has an anticancer mechanism by which the composition acts locally in a tumor tissue administered with the composition and shows a rapid antitumor effect (1-2 weeks after administration).

  本发明公开了一种用于局部给药的可注射抗癌组合物，其中含有盐酸奎宁悬浮液。本发明的局部给药抗癌组合物对 MKN-45 细胞的 IC50 值，经体外 MTT 试验测定，比紫杉醇低约 10 倍，表明该抗癌组合物具有良好的细胞毒性作用。在临床应用中，抗癌组合物可以作为一种安全的抗癌剂给药，还可以通过诱导实体癌细胞的坏死和脱落来显示抗癌效果。特别是，该抗癌组合物的抗癌机理是，该组合物在给药的肿瘤组织中起局部作用，并显示出快速的抗肿瘤效果（给药后 1-2 周）。
• Multifunctional (meth)acrylate manufacturing method
  申请人：TOAGOSEI CO., LTD.

  公开号：US10035752B2

  公开（公告）日：2018-07-31

  [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

  [问题]本发明的目的是通过季戊四醇或季戊四醇等多元醇与单官能团（甲基）丙烯酸酯的酯交换反应，获得收率高的多官能团（甲基）丙烯酸酯。 [解]一种多功能（甲基）丙烯酸酯的制造方法，其特征在于通过多元醇与单官能（甲基）丙烯酸酯的酯交换反应制造多功能（甲基）丙烯酸酯时，催化剂（A）和催化剂（B）一起使用。催化剂 (A)：一种或多种化合物，选自具有氮杂双环结构的环状叔胺或其盐或络合物、脒或其盐或络合物以及具有吡啶环的化合物或其盐或络合物组成的组。催化剂 (B)：一种或多种选自含锌化合物组的化合物。