奎尼丁二盐酸盐 | 85135-88-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 中文名称: 奎尼丁二盐酸盐
• 英文名称: Quinidine dihydrochloride
• 英文别名: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrochloride
• CAS: 85135-88-2
• 化学式: C20H26Cl2N2O2
• 分子量: 397.3
• InChiKey: NNKXWRRDHYTHFP-KAIFKDDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.02
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway
  申请人：——

  公开号：US20030186352A1

  公开（公告）日：2003-10-02

  This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

  本发明涉及利用不包括psbA或PPi磷酸果糖激酶、一般不在动物体内起作用或由质体DNA编码的植物类代谢途径的成分，来开发干扰表皮癣菌生长和存活的组合物。这些途径的成分包括酶、转运肽和编码酶和肽的核苷酸序列，或这些核苷酸序列的启动子，抗体、反义分子和其他抑制剂都是针对这些核苷酸序列的。诊断和治疗试剂及疫苗就是根据这些成分及其抑制剂开发出来的。
• Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components
  申请人：McLeod I. Rima

  公开号：US20050142113A1

  公开（公告）日：2005-06-30

  This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

  本发明涉及利用不包括psbA或PPi磷酸果糖激酶、一般不在动物体内起作用或由质体DNA编码的植物类代谢途径的成分，来开发干扰表皮癣菌生长和存活的组合物。这些途径的成分包括酶、转运肽和编码酶和肽的核苷酸序列，或这些核苷酸序列的启动子，抗体、反义分子和其他抑制剂都是针对这些核苷酸序列的。诊断和治疗试剂及疫苗就是根据这些成分及其抑制剂开发出来的。
• ANTIMICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON UNIQUE APICOMPLEXAN PARASITE COMPONENTS
  申请人：ARCH DEVELOPMENT CORPORATION

  公开号：EP0918868A2

  公开（公告）日：1999-06-02
• ANTI-MICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON APICOMPLEXAN PARASITE COMPONENTS
  申请人：Mcleod, Rima W.

  公开号：EP1150709A2

  公开（公告）日：2001-11-07
• US6699654B1
  申请人：——

  公开号：US6699654B1

  公开（公告）日：2004-03-02