1,2,4-三苄氧基苯 | 7298-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1,2,4-三苄氧基苯
• 英文名称: 1,2,4-tribenzyloxybenzene
• 英文别名: 1,3,4-tribenzyloxybenzene；1,2,4-Tribenzyloxybenzol；1,2,4-tris(phenylmethoxy)benzene
• CAS: 7298-33-1
• 化学式: C₂₇H₂₄O₃
• 分子量: 396.486
• InChiKey: URHCLZLFJKTWDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,4-三苄氧基苯 在 lithium aluminium tetrahydride 、 三溴化磷 、 sodium hydride 、 三氯氧磷 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 生成 5-(2-氨基乙基)苯-1,2,4-三醇盐酸盐
  参考文献：
  名称：

  2,4,5-三羟基苯丙氨酸（6-羟基多巴）的合成。一种中枢性去甲肾上腺素消耗剂。

  摘要：

  DOI：

  10.1021/jm00303a028
• 作为产物：
  描述：

  1,2,4-苯三酚 、 溴甲苯 以 N,N-二甲基甲酰胺 为溶剂， 以5%的产率得到2,4-dibenzyloxyphenol
  参考文献：
  名称：

  Polyphenolic Glycosides from African Proteaceae

  摘要：

  The phytochemical investigation of members of the genus Protea afforded a series of polyphenolic compounds (1-5) that were identified by 1D and 2D NMR experiments. Of these, 2-5 are new compounds. Chemical syntheses of 1-3 were performed in order to confirm the structures and to prepare additional material for biological evaluation.

  DOI：

  10.1021/np9902237

文献信息

• Stereoselective Syntheses of (-)-Podorhizol Lignan and its Derivatives:<i>erythro</i>and<i>threo</i>Preferential Aldol Condensation of Potassium Enolate from γ-Butyrolactone with Alkoxybenzaldehyde
  作者：Satoshi YAMAUCHI、Mitsuo MACHI、Yoshiro KINOSHITA

  DOI：10.1271/bbb.63.1453

  日期：1999.1

  (-)-Podorhizol (1) was stereoselectively synthesized by erythro preferential aldol condensation of 3,4,5-trimethoxy- benzaldehyde with potassium enolate from (+)-(R)-3- (3,4-methylenedioxybenzyl)-4-butanolide (2) (erythro:threo=85:15). Erythro selectivity was observed in the aldol condensation of many alkoxybenzaldehydes with potassium enolate from (+)-γ-butyrolactone 2. However, benzaldehydes having methoxy groups at both the 2 and 6 positions gave threo selectivity in the aldol condensation with potassium enolate from (+)-γ-butyrolactone 2.

  (-)-Podorhizol (1) 是通过 3,4,5-三甲氧基苯甲醛与来自 (+)-(R)-3-(3,4-二氧基苯甲基)-4-丁内酯 (2) 的钾烯醇进行红脆优先的醇缩合反应立体选择性合成的（红脆:反式=85:15）。在许多烷氧基苯甲醛与来自 (+)-γ-丁内酯 2 的钾烯醇的醇缩合反应中观察到了红脆选择性。然而，具有在 2 和 6 位均为甲氧基取代基的苯甲醛在与来自 (+)-γ-丁内酯 2 的钾烯醇的醇缩合反应中则表现出反式选择性。
• 一种儿茶素类化合物的制备方法
  申请人：中国人民解放军第二军医大学

  公开号：CN103833720B

  公开（公告）日：2016-05-11

  本发明涉及一种儿茶素类化合物的制备方法，所述的方法以2,4,6-三羟基苯乙酮，对羟基苯甲醛为原料，经缩合反应，还原脱氧，环氧化，酸催化的环合反应得到儿茶素类化合物。本发明优点在于：本发明提供一种可用于生产儿茶素类化合物工艺。在中间体9的合成过程中，本发明利用路易斯酸催化的硼氢化钠还原从而大大降低了由于双键转移而产生的副反应，而利用双氧水氧化代替了剧毒试剂四氧化锇。
• A novel aromatisation reaction of derivatives of 1,2-O-isopropylidene-myo-inositol
  作者：Patricia A. Gent、Roy Gigg

  DOI：10.1039/j39700002253

  日期：——

  Tetra-O-alkyl ethers of 1,2-O-isopropylidene-myo-inositol are converted into 1,2,4-trialkoxybenzenes on treatment with potassium t-butoxide in dimethyl sulphoxide at 80°. An intermediate product in the conversion of 3,4,5,6-tetra-O-benzyl-1,2-O-isopropylidene-myo-inositol into 1,2,4-trisbenzyloxybenzene was isolated. The intermediate, 3,4,5,6-tetrakisbenzyloxycyclohex-2-enol, was converted into 4,5

  在80℃下用叔丁醇钾在二甲基亚砜中处理，将1,2- O-异亚丙基-肌醇的四-O-烷基醚转化为1,2,4-三烷氧基苯。中间产品中的转化3,4,5,6-四ø -苄基-1,2- ö异亚丙基肌醇肌醇成1,2,4- trisbenzyloxybenzene分离。在用酸处理后，将中间体3,4,5,6-四烷基苄氧基环己二-2-烯醇转化为4,5,6-三苄氧基环己二-2-烯酮，后一种化合物在用碱处理后得到2,4-双苄氧基苯酚。
• <i>O</i>-BENZYLATION OF POLYPHENOLICS. PREPARATION OF 1,2,4-TRIBENZYLOXYBENZENE
  作者：Uffe Anthoni、Carsten Christophersen、Per Halfdan Nielsen

  DOI：10.1081/scc-100104477

  日期：2001.1.1

  The main phenolic by-products in the O-benzylation of 1,2,4-trihydroxy- or 1,2,4-triacetoxybenzene to 1,2,4-tribenzyloxybenzene have been identified as due to incomplete O-benzylation and C-benzylation. In addition, dibenzyldimethyl-ammonium chloride is formed from DMF and benzyl chloride. The main factors controlling these reactions paths are discussed. An efficient procedure for preparing 1,2,4-tribenzyloxybenzene using NaH in DMF is reported.
• WAVE LENGTH CONVERSION MEMBER, BACK LIGHT UNIT, LIQUID CRYSTAL DISPLAY DEVICE, AND QUANTUM DOT-CONTAINING POLYMERIZABLE COMPOSITION
  申请人：FUJIFILM Corporation

  公开号：US20150330602A1

  公开（公告）日：2015-11-19

  A wavelength conversion member including a wavelength conversion layer comprising a quantum dot, wherein the wavelength conversion layer includes an organic matrix, and the organic matrix contains a polymer and one or more of compounds selected from the group consisting of compounds represented by general formula (1) and the like; and a quantum dot-containing polymerizable composition containing a quantum dot, a radical polymerizable compound, and one or more of compounds selected from the group consisting of compounds represented by general formula (1) and the like are provided. The wavelength conversion member has an excellent light resistance and the composition has an excellent photocurability which enables a production of a wavelength conversion member containing a quantum dot which has a less tendency to lower its light emission intensity.