戊乙二醇二甲烷磺酸酯 | 109789-39-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 戊乙二醇二甲烷磺酸酯
• 英文名称: Pentaethylene Glycol Dimethanesulfonate
• 英文别名: 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethanol;methanesulfonic acid
• CAS: 109789-39-1
• 化学式: C12H30O12S2
• 分子量: 430.5
• InChiKey: RZWHFBDTVDZPJE-UHFFFAOYSA-N

物化性质

• 沸点：
  560.1±50.0 °C(Predicted)
• 密度：
  1.285±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于二氯甲烷、乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -1.95
• 重原子数：
  26
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  203
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• Flavonoid Dimers and Methods of Making and Using Such
  申请人：Chan Tak-Hang

  公开号：US20090197943A1

  公开（公告）日：2009-08-06

  Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.

  多药耐药性（MDR）是癌症化疗中的主要问题。最好表征的耐药机制是通过过度表达药物外流转运蛋白、渗透性糖蛋白（P-gp）介导的耐药机制，它将各种抗癌药物泵出细胞，导致细胞内药物积累降低。本发明开发了一系列由不同长度的连接基团连接在一起的类黄酮二聚体。发现这些类黄酮二聚体是有效的P-gp调节剂，可以增加抗癌药物在体外的细胞毒性并显著提高它们的细胞内药物积累。同时，发现本发明的类黄酮二聚体也有助于减少治疗寄生虫病的耐药性。
• FLAVONOID DIMERS AND METHODS OF MAKING AND USING SUCH
  申请人：The Hong Kong Polytechnic University

  公开号：EP2029568A1

  公开（公告）日：2009-03-04
• US8710097B2
  申请人：——

  公开号：US8710097B2

  公开（公告）日：2014-04-29
• [EN] FLAVONOID DIMERS AND METHODS OF MAKING AND USING SUCH<br/>[FR] DIMÈRES DE FLAVONOÏDES, ET PROCÉDÉS CORRESPONDANTS DE FABRICATION ET D'UTILISATION
  申请人：UNIV HONG KONG POLYTECHNIC

  公开号：WO2007135592A1

  公开（公告）日：2007-11-29

  [EN] Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over- expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.
  [FR] La résistance pléiotrope pose un problème important en chimiothérapie anticancéreuse. Le mécanisme de résistance le mieux caractérisé a comme médiateur la surexpression des transporteurs d'effluence des médicaments, la P-glycoprotéine (P-gp), qui pompent divers médicaments anticancéreux hors des cellules, ce qui aboutit à une diminution de l'accumulation intracellulaire des médicaments. L'invention propose ainsi une gamme de dimères de flavonoïdes liés entre eux par des groupes de liaison de diverses longueurs. Ces dimères de flavonoïdes s'avèrent des modulateurs efficaces de la P-gp qui accroissent la cytotoxicité des médicaments anticancéreux in vitro et renforce de façon considérable leur effet d'accumulation intracellulaire des médicaments. Il s'avère en outre que les dimères de flavonoïdes de l'invention conviennent également pour la réduction de la résistance aux médicaments pour le traitement des maladies parasitaires.