(2R,3R,4R,5S,6R)-2-[(2R,3S,4R,5S)-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-5-[(2R,3R,4S,6S)-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R,5S,6R)-2-[(2R,3S,4R,5S)-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-5-[(2R,3R,4S,6S)-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4-diol
• 化学式: C₁₈H₃₂O₁₄
• 分子量: 472.4
• InChiKey: OJXALCHGLCMKDO-SKPCJRIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  228
• 氢给体数：
  9
• 氢受体数：
  14

文献信息

• Antibodies, uses thereof and conjugates thereof
  申请人：Polytherics Limited

  公开号：US11485792B2

  公开（公告）日：2022-11-01

  An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequence given in SEQ ID NO:33, wherein SEQ ID NO:33 is: EVQLVQSGX9E X11KKPGASVKV SCKX24SGYTFT EYTIHWVX38QA X41 GKGLEWIGN INPNX55GGTTY NOKFEDRX68TX70 TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFDYWGOGTT VTVSS wherein: X9 is A or P X11 is V or L X24 is A or T X38 is R or K X41 is P or H X55 is N or Q X68 is V or A; and X70 is I or L whereby the heavy chain variable domain comprises up to 3 amino acid sequence modification(s) between positions 1-30, 36-49, 67-98 and 105-115 of SEQ ID NO: 33. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer.

  一种抗体或其抗原结合部分，该抗体或其抗原结合部分与 PSMA 结合并包含一个重链可变结构域，该结构域包含 SEQ ID NO:33 中给出的序列，其中 SEQ ID NO:33 为：EVQLVQSGX9E X11KKPGASVKV SCKX24SGYTFT EYTIHWVX38QA X41 GKGLEWIGN INPNX55GGTTY NOKFEDRX68TX70 TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFDYWGOGTT VTVSS 其中：X9 是 A 或 P X11 是 V 或 L X24 是 A 或 T X38 是 R 或 K X41 是 P 或 H X55 是 N 或 Q X68 是 V 或 A；以及 X70 是 I 或 L 其中重链可变结构域包括 SEQ ID NO: 33 的 1-30、36-49、67-98 和 105-115 位之间的多达 3 个氨基酸序列修饰。本发明还提供了包括其抗体或抗原结合部分的化合物，如共轭物，以及它们在治疗或诊断疾病，特别是癌症，尤其是前列腺癌中的用途。
• ANTIBODIES, USES THEREOF AND CONJUGATES THEREOF
  申请人：Polytherics Limited

  公开号：US20190144562A1

  公开（公告）日：2019-05-16

  An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequence given in SEQ ID NO:33, wherein SEQ ID NO:33 is: EVQLVQSGX 9 E X 11 KKPGASVKV SCKX 24 SGYTFT EYTIHWVX 38 QA X 41 GKGLEWIGN INPNX 55 GGTTY NOKFEDRX 68 TX 70 TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFDYWGOGTT VTVSS wherein: X 9 is A or P X 11 is V or L X 24 is A or T X 38 is R or K X 41 is P or H X 55 is N or Q X 68 is V or A; and X 70 is I or L whereby the heavy chain variable domain comprises up to 3 amino acid sequence modification(s) between positions 1-30, 36-49, 67-98 and 105-115 of SEQ ID NO: 33. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer.